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《International Journal of Laboratory Medicine》 2019-10
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Establishment of serum FT3,FT4 and TSH reference intervals for children of 0-3 years by laboratory information system

SU Hanwen;GU Jian;HE Bing;Department of Clinical Laboratory,Renmin Hospital of Wuhan University;Department of Pediatrics,Renmin Hospital of Wuhan University;  
Objective To establish the reference intervals of free Triiodothyronine(FT3),free thyroxine(FT4)and thyroid stimulating hormone(TSH)for children of 0-3 years children by laboratory information system(LIS)from hospital-stored data in Renmin Hospital of Wuhan University.Methods A total of 29 169 cases with the age of 0-3 years of the test results of serum FT3,FT4 and TSH stored in the LIS of Renmin Hospital of Wuhan University from July 2013 to December 2017 were collected and divided into group A(1 d-≤1 month),group B(1-≤12 months)and group C(1-≤3 years),and after data screening,R-language programming and linear fitting were used to establish the indirect reference intervals.Results The reference intervals of group A were:FT3 2.12-7.42 pmol/L,FT4 10.87-31.20 pmol/L and TSH 0.681-18.673μIU/mL,the group B were FT3 4.34-7.61 pmol/L,FT4 10.90-20.14 pmol/L and TSH 0.388-5.401μIU/mL;the group C were FT3 4.05-7.41 pmol/L,FT4 11.28-20.50 pmol/L,TSH 0.279-5.139μIU/mL.There was no statistically significant difference(P0.05)on the FT3,FT4,TSH reference intervals between the existing reference ranges established by healthy individuals and using LIS storage data.Conclusion Application of LIS to establish the reference intervals is economy,simple and feasible,which can be used as a choice of the reference interval of the laboratory.
【Fund】: 湖北省自然科学基金科技支撑计划项目(2016CFB648)
【CateGory Index】: R446.1
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