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《International Journal of Laboratory Medicine》 2019-10
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Chemotherapy effect of paclitaxel combined with capecitabine in patients with advanced gastric cancer and changes of serum endostatin and VEGF

JIANG Chengchuan;LIU Sha;ZHAO Huiping;LI Xiangjun;YANG Zhou;TANG Sanyuan;Department of Oncology,the Second People′s Hospital/Hunan Brain Hospital;  
Objective To analyze the chemotherapy effect of paclitaxel combined with capecitabine in patients with advanced gastric cancer and changes of serum endostatin and VEGF.Methods A total of 90 patients with advanced gastric cancer,who were treated in hospital from April 2014 to April 2016,were selected and divided into the control group and study group by random number table,45 cases in each group.On the basis of conventional treatment,the control group were added with cisplatin combined with capecitabine chemotherapy,while the study group were added with paclitaxel combined with capecitabine chemotherapy.To compare the recent clinical effects,adverse events,survival of 1-year follow-up and changes of serum tumor markers like CEA,CA72-4,CA19-9,endostatin,VEGF levels in the two groups.Results The total effective rate and disease control rate of the study group [40.0%(18/45),73.3%(33/45)]were higher than those of the control group[22.2%(10/45),51.1%(23/45)]with statistically significant difference(χ~2=4.558,4.727;P=0.033,0.030).After treatment,the levels of CEA,CA72-4,CA19-9 and VEGF in the study group were significantly lower than those in the control group,but the level of indostatin was prominently higher than that in the control group,with statistically significant difference(t=9.608,13.781,4.668,7.623,5.331;P=0.000).The difference on adverse reactions like stomatitis,nausea and vomiting,leukopenia,hemoglobin reduction,thrombocytopenia,diarrhea,hand and foot syndrome,sodium and water retention,peripheral nerve toxicity and hair loss during chemotherapy in both groups had no statistical significance(χ~2=0.505,0.518,0.916,0.442,0.121,0.145,0.100,0.471,0.104,0.412;P=0.478,0.472,0.338,0.506,0.728,0.703,0.752,0.492,0.747,0.521).The difference on 1-year survival rate between the study group [51.1%(23/45)]and the control group[40.0%(18/45)]was statistically significant difference(χ~2=2.272;P=0.132).Conclusion Paclitaxel combined with capecitabine chemotherapy is effective in patients with advanced gastric cancer,and it can significantly reduce the levels of serum tumor markers and VEGF levels and increase endostatin level.
【Fund】: 长沙市科技局科研资金资助项目(k1403066-31)
【CateGory Index】: R735.2
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【Citations】
Chinese Journal Full-text Database 9 Hits
1 Xi Hongqing;Zhang Kecheng;Wei Bo;Chen Lin;Department of General Surgery,Chinese People's Liberation Army General Hospital;;Significance and contemplation of clinical diagnosis and therapy on the renewal of the eighth edition of gastric cancer TNM staging system[J];中华胃肠外科杂志;2017-02
2 Zhang Baihong;Yue Hongyun;Department of Oncology,Lanzhou General Hospital of Lanzhou Military Region;;Brief introduction of response evaluation criteria in solid tumors[J];国际肿瘤学杂志;2016-11
3 Wang Jian;Yu Jingping;Wang Jianlin;Ni Xinchu;Sun Zhiqiang;Sun Wei;Nie Bin;Jiang Jingting;Sun Suping;Wu Changping;Department of Tumor Biological Treatment,Third Affiliated Hospital of Soochow University;Department of Radiotherapy,the Changzhou Second People's Hospital,Affiliated Hospital of Nanjing Medical University;;Pathologic response and changes of serum VEGF during chemoradiotherapy may predict prognosis in non-surgical patients with esophageal carcinoma[J];中华肿瘤杂志;2016-08
4 Zhu Zhenggang;Department of Surgery,Ruijing Hospital,Shanghai Jiaotong University School of Medicine,Shanghai Institute of Digestive Surgery;;Clinical efficacy of paclitaxel combined with S-1 in the prevention and treatment of gastric cancer with peritoneal metastasis[J];中华胃肠外科杂志;2015-10
5 Shen Dong;Song Yu;Department of Internal Medicine Oncology,the First People's Hospital of Zhangjiagang;;Capecitabine maintenance in the treatment of recurrence and metastasis of gastric cancer after operation[J];现代肿瘤医学;2015-18
6 LI Xingyu;LIANG Jing;LI Yan;Department of Chemotherapy,Cancer Center,Qianfoshan Hospital Affiliated to Shandong University;;Antitumor effect of endostatin synergized with tumor special DC-T cellular therapy[J];山东大学学报(医学版);2015-07
7 Zheng Jiarong;Zhang Min;Xu Ri;Xu Fengliang;Department of Clinical Laboratory,People's Hospital of Rizhao Affiliated to Jining Medical University;Shandong University;;Clinical application of tumor markers combined with motion detection in diagnosis and treatment monitoring in gastric cancer[J];中华临床医师杂志(电子版);2015-03
8 XIONG Zhong-tang;ZHANG Sheng;WANG Xing-fu;ZHENG Ke;CHEN Hong;CHEN Yu-peng;Department of Pathology,the First Affiliated Hospital of Fujian Medical University;Department of Pathology,the Third Affiliated Hospital of Guangzhou Medical University;;Expression of Par3,Par6 and a PKC in gastric carcinoma and their significance[J];临床与实验病理学杂志;2014-12
9 CAO Lei;SHAN Xiuhong;WANG Yafei;CHEN Yerong;NI Enzhen;LIU Yuanbin;Department of Radiology,the Affiliated People's Hospital of Jiangsu University;;Comparison of diagnostic value in different parts and staging gastric cancer with 64-slice spiral CT[J];实用放射学杂志;2014-05
【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 Yang Zhiguo;Liu Zengfu;Department of Oncology Heze Municipal Hospital;Department of Gastroenterology Heze Municipal Hospital;;XELOX chemotherapy combined with thalidomide for colorectal cancer and its effect on TAP and APC[J];国际医药卫生导报;2018-18
2 Liu Huilan;Wang Jianlin;Dai Shengbin;Yu Bo;Sha Sha;Shu Zhongqin;Gu Xiaowei;Wang Jian;Department of Tumor,Taizhou People's Hospital;Department of Radiotherapy,Changzhou Second People' s Hospital,Affiliated Hospital of Nanjing Medical University;Department of Radiotherapy,Jiangyin People' s Hospital;;Risk factors for radiation esophagitis and pneumonitis in esophageal cancer patients with diabetes or hypertension[J];中华放射医学与防护杂志;2018-08
3 YI Ze-jun;WU Jian-ping;Sichuan Jiaojiang County Maternal and Child Health Institute;;Changes of T Cell Immune Function in Patients with Liver Cancer Treated by Minimally Invasive Interventional Therapy[J];医学临床研究;2018-07
4 Sun Wei;Sun Zhiqiang;Wang Jianlin;Yu Jingping;Ni Xinchu;Nie Bin;Li Yi;Sun Suping;Wang Jian;Department of Radiotherapy,The Affiliated Changzhou No.2 People' s Hospital of Nanjing Medical University;;Association between pathological response or VEGF serum changes during radiotherapy and prognosis in patients with esophageal carcinoma[J];中华放射医学与防护杂志;2018-07
5 Zhu Zhenggang;Department of Surgery,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai Institute of Digestive Surgery,Shanghai Key Laboratory of Gastric Neoplasm;;Clinical significance and practice points of conversion therapy for gastric cancer with peritoneal metastasis[J];中华胃肠外科杂志;2017-10
6 Liu Weizhen;Wan Wenze;Ruan Tuo;Zhu Xiaojie;Wang Guobin;Tao Kaixiong;Wu Chuanqing;Department of Gastrointestinal Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology;;Effect of PARD3 on metastasis of colorectal cancer[J];中华实验外科杂志;2017-10
7 Dou Hongmei;Hong Hua;Wang Yuanjie;Zhao Xiaojun;Operating Room,Taizhou People's Hospital,Jiangsu Province;Gastrointestinal Surgery,Taizhou People's Hospital,Jiangsu Province;;Effects of different peritoneal lavage methods on prognosis in patients after radical gastrectomy[J];中华现代护理杂志;2017-26
8 WANG Xiaoxiao;SHAN Xiuhong;PAN Donggang;JIA Yingjun;NI Enzhen;HU Yuan;Department of Radiology,the Affiliated People's Hospital of Jiangsu University;;Value of MSCT in the diagnosis of metastatic lymph nodes of gastric cancer[J];实用放射学杂志;2017-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Ren Wei;Yan Jing;Qian Xiaoping;;Research Progress in Nonsnrgjcal Treatment Response Evaluation Criteria for Esophageal Cancer[J];中华肿瘤杂志;2014-09
2 Zhen Zhenhua;Shen Chuanhou;Tao Xiongfei;Department of Oncology,People's Hospital of Huaibei;;Clinical observation of capecitabine maintain treatment on metastatic breast cancer[J];现代肿瘤医学;2014-07
3 Jing-Ping Yu;Su-Ping Sun;Zhi-Qiang Sun;Xin-Chu Ni;Jian Wang;Yi Li;Li-Jun Hu;Dong-Qing Li;Department of Radiation Oncology,Changzhou Second People’s Hospital,Affiliated to Nanjing Medical University;;Clinical trial of thalidomide combined with radiotherapy in patients with esophageal cancer[J];World Journal of Gastroenterology;2014-17
4 Zhang Xuemei;She Chunyan;Xu Chong'an;Department of Medical Oncology,The 4th Affiliated Hospital of China Medical University;;Clinical study of chemotherapy on aged patients with advanced gastric carcinoma[J];现代肿瘤医学;2014-04
5 Ren Hua;Wang Xin;Fang Hui;Li Ning;Jin Jing;Liu Yueping;Wang Weihu;Wang Shulian;Song Yongwen;Li Yexiong;Department of Radiation Oncology,Cancer Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College;;Interim assessment of prospective phase Ⅱ trial evaluating efficacy of intensity-modulated radiotherapy with concurrent capecitabine for stage Ⅱ/Ⅲ gastric cancer after radical surgery[J];中华放射肿瘤学杂志;2014-02
6 NIU Jian-hua;FENG Guang-kun;CONG Zhi-liang;GUO Liang;GAO Hong-li;ZHANG Zhao-ming;NIU Xue-cai;LI Jing;Forth People's Hospital of Jinan;;Domestic Meta-analysis of capecitabine combined with other drugs as neoadjuvant therapy in advanced gastric cancer[J];中华肿瘤防治杂志;2014-04
7 LU Jian-jun;MA Jun;MIAO Rong;GU Yong;ZHONG Fo-tian;Department of Thoracic Surgery,The First Affiliated Hospital,Sun Yat-sen University;;Expression of vascular endothelial growth factor D in human esophageal squamous cell carcinoma tissue and its significance[J];中华胃肠外科杂志;2013-12
8 ZHAO Qun;LI Yong;TAN Bi-bo;TIAN Yuan;JIAO Zhi-kai;ZHAO Xue-feng;ZHANG Zhi-dong;WANG Dong;YANG Pei-gang;Department of General Surgery,the Fourth Affiliated Hospital,Hebei Medical University;;Effects of XELOX regimen as neoadjuvant chemotherapy on radical resection rate and prognosis in patients with advanced gastric cancer[J];中华肿瘤杂志;2013-10
9 Wu Yungaowa,Li Wenxin,Bao Jiaqi,Sha Rula,Su Rila People' Hospital of Inner Mongolia Autonomous Region,Inner Mongolia Huhhot 010017,China.;Clinical effect of maintenance chemotherapy by pemetrexed in advanced non-small cell lung cancer(NSCLC)[J];现代肿瘤医学;2013-08
10 GONG Long-bo;LV Xiao-peng;MENG Liang;XIA Hong;XIE Zhi-yuan;XU Yu-zhen;Department of General Surgery,Xuzhou Hospital,Medical College of Southeast University;;Clinical analysis of neoadjuvant chemotherapy with capecitabine and oxaliplatin(XELOX) in stage Ⅲ advanced gastric cancer[J];中华临床医师杂志(电子版);2013-15
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