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《International Journal of Laboratory Medicine》 2019-10
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Chemotherapy effect of paclitaxel combined with capecitabine in patients with advanced gastric cancer and changes of serum endostatin and VEGF

JIANG Chengchuan;LIU Sha;ZHAO Huiping;LI Xiangjun;YANG Zhou;TANG Sanyuan;Department of Oncology,the Second People′s Hospital/Hunan Brain Hospital;  
Objective To analyze the chemotherapy effect of paclitaxel combined with capecitabine in patients with advanced gastric cancer and changes of serum endostatin and VEGF.Methods A total of 90 patients with advanced gastric cancer,who were treated in hospital from April 2014 to April 2016,were selected and divided into the control group and study group by random number table,45 cases in each group.On the basis of conventional treatment,the control group were added with cisplatin combined with capecitabine chemotherapy,while the study group were added with paclitaxel combined with capecitabine chemotherapy.To compare the recent clinical effects,adverse events,survival of 1-year follow-up and changes of serum tumor markers like CEA,CA72-4,CA19-9,endostatin,VEGF levels in the two groups.Results The total effective rate and disease control rate of the study group [40.0%(18/45),73.3%(33/45)]were higher than those of the control group[22.2%(10/45),51.1%(23/45)]with statistically significant difference(χ~2=4.558,4.727;P=0.033,0.030).After treatment,the levels of CEA,CA72-4,CA19-9 and VEGF in the study group were significantly lower than those in the control group,but the level of indostatin was prominently higher than that in the control group,with statistically significant difference(t=9.608,13.781,4.668,7.623,5.331;P=0.000).The difference on adverse reactions like stomatitis,nausea and vomiting,leukopenia,hemoglobin reduction,thrombocytopenia,diarrhea,hand and foot syndrome,sodium and water retention,peripheral nerve toxicity and hair loss during chemotherapy in both groups had no statistical significance(χ~2=0.505,0.518,0.916,0.442,0.121,0.145,0.100,0.471,0.104,0.412;P=0.478,0.472,0.338,0.506,0.728,0.703,0.752,0.492,0.747,0.521).The difference on 1-year survival rate between the study group [51.1%(23/45)]and the control group[40.0%(18/45)]was statistically significant difference(χ~2=2.272;P=0.132).Conclusion Paclitaxel combined with capecitabine chemotherapy is effective in patients with advanced gastric cancer,and it can significantly reduce the levels of serum tumor markers and VEGF levels and increase endostatin level.
【Fund】: 长沙市科技局科研资金资助项目(k1403066-31)
【CateGory Index】: R735.2
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