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《International Journal of Laboratory Medicine》 2019-10
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Performance analysis of fluorescence in situ hybridization combined with urinary exfoliative cytology and bladder tumor antigen in the diagnosis of urothelial cell carcinoma

XIONG Zuan;MEI Yufeng;WANG Chunyang;WEI Baozhen;LIU Ping;WANG Ya;SHEN Lihua;LIU Qing;Clinical Laboratory,Ezhou Iron and Steel Hospital;Clinical Laboratory,Ezhou Maternal and Child Health Hospital;  
Objective To analyze the effect of UroVysion fluorescence in situ hybridization,urine exfoliative cytology and bladder tumor antigen in the diagnosis of upper urinary tract carcinoma,and to provide a theoretical basis for the diagnosis of upper urinary tract epithelial cell carcinoma.Methods A total of 105 patients with urothelial cell carcinoma diagnosed by cystoscope biopsy in the department of urology in Urinary Surgery of the hospital from 2014 to 2017 were selected as the observation group,and 100 cases that took the normal physical examination in the same period were selected as control group.To observe and analyze the effect of UroVysion fluorescence in situ hybridization,urine exfoliated cytology and bladder tumor antigen(BTA)in the diagnosis of upper urinary tract carcinoma.Results The sensitivity and specificity of UroVysion fluorescence in situ hybridization were 81.90% and 92.00%respectively,while the sensitivity and specificity of urine exfoliative cytology combined with BTA were 37.14% and 93.00%,respectively,and the sensitivity of the former is significantly higher than that of the latter,with statistically significant difference(P0.05),but the specificity showed no statistically significant difference(P0.05).With the grading of upper urinary epithelial cell carcinoma,the positive rate of detection of two methods increased gradually.However,the detection rate of UroVysion fluorescence in situ hybridization was significantly higher than that of urine cytology and BTA,with statistically significant difference(P0.05).The sensitivity,specificity and accuracy of the combination of three methods were significantly higher than those of UroVysion in situ hybridization alone,urine cytology combined with BTA.Conclusion The sensitivity and specificity of detection of UroVysion fluorescence in situ hybridization on urothelial cell carcinoma are better,with a safe rapid and noninvasive detection method,detection of antigen shedding cytology combined with BTA combined with urine can significantly improve the diagnosis of upper urinary tract transitional cell carcinoma of the accuracy,with good application prospect.
【Fund】: 国家自然科学基金项目(201602378)
【CateGory Index】: R737.1;R730.43
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