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《International Journal of Laboratory Medicine》 2019-10
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Bacteria distribution and antibiotic resistance of extended spectrum β-lactamases in neonates with respiratory tract infection

HE Xiao;SHEN Yan;ZHONG Wen;XIE Qian;LI Qiuhong;Departmen of Clinical Laboratory,Chongqing Health Center for Women and Children;Department of Neonatology,Chongqing Health Center for Women and Children;  
Objective To study the distribution characteristics and antibiotic resistance of extended spectrumβ-lactamases(ESBLs)in neonates with respiratory tract infection,in order to guide rational antibacterial therapy.Methods The ESBLs-producing bacteria and non ESBLs-producing bacteria of respiratory tract infection separated from Department of Neonatology of the hospital from January 2013 to September 2018 were collected to conduct drug sensitive test by broth dilution method.Results Among the ESBLs-producing bacteria with neonatal respiratory infection,Klebsiella pneumoniae accounted for 72.73%,Escherichia coli 27.27%.The detection rates of ESBLs in Klebsiella pneumoniae and Escherichia coli were 48.24%and 28.12%,respectively.The resistant rate of ESBLs-producing bacteria to some antimicrobial agents were significantly higher than that of non-ESBLs-producing bacteria,with statistically significant difference(P0.05).The resistant rate of ESBLs-producing Klebsiella pneumoniae to Amoxicillin-clavulanic,ampicillin-shubatan or piperacillintazobactam were 29.17%,90.63% and 57.29% respectively,while the resistant rates of ESBLs-producing Escherichia coli were 8.33%,38.89%and 2.78%respectively.The multiple antibiotic resistance rates of the ESBLs-producing Klebsiella pneumoniae and the ESBLs-producin Escherichia coli were 97.92%and 88.89%,respectively.Conclusion Detection rate of ESBLs-producing strains is high in respiratory tract infections of neonates,and the multiple antibiotic resistance rates of the ESBLs-producing bacteria causes neonatal respiratory tract are higher than those in adults.Antimicrobial test in vitro shows that the resistance rates of different combinations of beta-lactams and beta-lactamase inhibitors are differently in neonatal respiratory tract,which will be positive significance in guiding the clinical administration of drugs.
【Fund】: 重庆市卫生健康委员会医学科研项目(2012-2-208)
【CateGory Index】: R722.13;R446.5
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