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《International Journal of Laboratory Medicine》 2019-10
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Effects of dapagliflozin on β islet cell function and lipid metabolism disorder in newly diagnosed T2MD patients with central obesity

JIAN Xiaohong;XU Jianbin;SHEN Jing;Department of Endocrinology ,The 8th Medical Center of Chinese PLA General Hospital;  
Objective To explore the effects of dapagliflozin onβislet cell function and lipid metabolism disorder in newly diagnosed type 2 diabetes mellitus(T2 MD)patients with central obesity.Methods A total of 106 T2 DM patients with central obesity,who were received in the hospital from August 2017 to March2018,were divided into control group and observation group according to the computer random number method,53 cases in each group.Both groups were given dietary control and exercise therapy,and the control group was added with metformin on this basis,and the observation group was added with metformin combined with dapagliflozin.The BMI index,waist circumference,glucose metabolism [fasting plasma glucose(FPG),postprandial 2 hblood glucose(2 hPG),glycosylated hemoglobin(HbA1 c)],lipid metabolism [total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)]and isletβcell function[index ofβ-cell function in HOMA(HOMA-β)and homeostasis model assessment of insulin resistance(HOMA-IR)]were observed in both groups before and after treatment.Results After 24 weeks of treatment,the BMI index,waist circumference,HOMA-IR,serum levels of FPG,2 hPG,HbA1 c,TC,TG and LDL-C in the two groups were lower than those before treatment,and the above indexes in the observation group were lower than those in the control group(P0.05),and serum HDL-C level and HOMA-βwere higher than those before treatment,and the both indexes in the observation group were higher than those in the control group,the difference had statistical significance(P0.05).Conclusion Dapagliflozin has good efficacy in the treatment of T2 DM patients with central obesity,and it can significantly reduce body weight,narrow waist circumference,lower levels of blood glucose and blood lipids,and promote recovery of isletβcell function.
【CateGory Index】: R587.1
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1 Yang Juhong;Kong Yan;Zhang Liyi;Shan Chunyan;Department of Diabetic Nephropathy,Key Laboratory of Hormones and Development(Ministry of Health),Tianjin Key Laboratory of Metabolic Diseases,The Metabolic Diseases Hospital & Tianjin Institute of Endocrinology,Tianjin Medical University;;Effects of hypoglycemic agents on cardiovascular outcome[J];国际内分泌代谢杂志;2017-05
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