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《International Journal of Laboratory Medicine》 2019-10
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Expression level of serum SCC-Ag and CYFRA21-1 in patients with cervical cancer and its clinical significance

TANG Zhen;Department of Clinical Laboratory,Suzhou Municipal Hospital;  
Objective To analyze the expression level of serum SCC-Ag and CYFRA21-1 in patients with cervical cancer and its clinical significance.Methods Totally 34 patients with cervical cancer,who were treated in the hospital from March 2014 to February 2017,were selected as group A,simultaneously,31 patients with intraepithelial neoplasia of cervical cancer were selected as group B and 30 healthy women who underwent physical examination in the hospital were selected as group C.Serum SCC-Ag and CYFRA21-1 levels in all the groups were measured among patients with different tissue types and different clinical stages.Results The results of ANOVA showed that there were statistically significant difference on the levels of serum SCC-Ag and CYFRA21-1 among the three groups(P0.05).The levels of serum SCC-Ag and CYFRA21-1 in the group A were higher than those in the group B and group C,while the level of serum SCC-Ag in the group B was higher than that in the group C,the difference showed statistical significance(P0.05).The serum levels of SCCAg,CYFRA21-1 from low to high were patients with cervical cancer in stageⅠ,stageⅡ,and stageⅢ-Ⅳsuccessively,there was statistically significant difference(P0.05).The positive rate of serum SCC-Ag in patients with squamous cell carcinoma was significantly higher than that in patients with adenocarcinoma and adenosquamous carcinoma,and the positive rate of serum CYFRA21-1 in patients with adenosquamous carcinoma was significantly higher than that in patients with squamous cell carcinoma and adenocarcinoma,the difference had statistical significance(P0.05).The sensitivity,accuracy and specificity of serum SCC-Ag combined with CYFRA21-1 in the diagnosis of cervical cancer were 0.971,0.952 and 0.828,respectively.ConclusionThe expression level of serum SCC-Ag and CYFRA21-1 significantly increased in patients with cervical cancer,the combined detection of serum SCC-Ag and CYFRA21-1 can be used as an important index for clinical diagnosis and prognosis evaluation of cervical cancer patients.
【CateGory Index】: R737.33;R730.43
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