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《International Journal of Laboratory Medicine》 2019-10
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Inhibitory effect of Triptolide on angiogenesis and inflammation in LPS-induced human osteosarcoma cells MG-63

LIN Miaoxiong;PENG Ming;DU Guoyou;CHEN Yan;LIN Huiling;Department of Blood Transfusion and Clinical Laboratory,Zhongshan Traditional Chinese Medicine Hospital;Department of Surgery,Zhongshan Traditional Chinese Medicine Hospital;Department of Emergency,Zhongshan Traditional Chinese Medicine Hospital;  
Objective To study the inhibitory effect of Triptolide on angiogenesis and inflammation in LPSinduced human osteosarcoma cells MG-63 and explore the underlying mechanism of this protective effect.Methods LPS(10μg/mL)was adopted to stimulate human osteosarcoma cells MG-63 to establish a model of disease inflammation.MTT assay was used to detect the viability of human osteosarcoma cells MG-63.Angiogenesis and inflammatory cytokines expression were detected by the method of quantitative real time PCR and enzyme linked immunosorbent assay.p-p38 protein expression was examined by the Western blot.ResultsTriptolide(50-200μg/mL)could significantly suppress the expression and release of TNF-α,IL-6,HIF-1αand VEGF.Conclusion Triptolide can significantly suppress angiogenesis and inflammatory cytokines expression in LPS-stimulated human osteosarcoma cells MG-63,likely by inhibiting p-p38 signaling pathway.
【Fund】: 2016年中山市卫生和计划生育局医学科研项目(2016J072)
【CateGory Index】: R738
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