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《International Journal of Laboratory Medicine》 2019-10
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The value of PLR,NLR parameters combined with tumor markers in the diagnosis of non-small cell lung cancer

LU Xingbing;SHI Jia;LI Qin;LIU Bo;CHEN Juan;ZENG Sugen;XIE Yi;Department of Laboratory Medicine,West China Hospital/West China School of Medicine,Sichuan University;  
Objective To explore the clinical value of partial blood cell parameters(PLR),neutrophils and lymphocyte ratio(NLR),neuron-specific enolase(NSE),cytokeratin 19 fragments(Cyfra21-1)and carcinoembryonic antigen(CEA)to the auxiliary diagnosis of non small cell lung cancer(NSCLC).Methods The clinical data of 364 cases of NSCLC patients,who were received in the hospital from April 2016 to December2017,were collected as the study group,simultaneously 209 patients with benign lung diseases were collected as control group.Blood routine analyzer and electrochemilu minescene immunoassay were adopted to detect the parameters of PLR,NLR,NSE,Cyfra21-1 and CEA and the five parameters in the two groups were compared.Results The five parameters in the study group were higher than thosein the control group,with statistically significant difference(P0.05).The results of PLR and Cyfra21-1 in patients with lung squamous cell carcinoma were significantly higher than those in patients with adenocarcinoma,but the result of CEA in patients was with lung squamous cell carcinoma lower than that in patients with adenocarcinoma,the difference showed statistical significance(P0.05).The results of NSE,Cyfra21-1 and CEA in the clinical III/IV period were higher than those in the I/II stage,and the whole results of the T3,T4 stages were higher than those of T1,T2 stages,the difference had statistical significant(P0.05).The five parameters were correlated with NSCLC,the area ROC curve of combination detection of 5 parameters was the largest(0.829)and the sensitivity and accuracy of the combination detection were significantly higher than any single index,with statistically significant difference(P0.05),however,the specificity of combination was significantly lower than single detection,with statistically significant difference(P0.05).Conclusion The five parameters of PLR,NLR,NSE,Cyfra21-1 and CEA are over-expression in patients with NSCLC,and there is correlation with clinical pathology and TNM stage.The combination detection can significantly improve the detection efficiency,sensitivity,accuracy and positive rate in the auxiliary diagnosis of NSCLC,and provide reliable clinical predictive value for NSCLC early diagnosis,treament and prognosis monitoring.
【CateGory Index】: R734.2;R730.43
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