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《International Journal of Laboratory Medicine》 2019-10
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Dynamic expression and significance of ADPN,hs-CRP and IL-6 in acute cerebral infarction

YE Shengshou;WANG Xinlan;YAN Xingli;QI Xiuli;Department of Neurology,Qinghai Specialized Hospital of Cardiovascular and Cerebrovascular Diseases;Department of Neurology,Liaoyang Central Hospital;  
Objective To investigate the relationship of ADPN,hs-CRP and IL-6 and the occurrence and development of acute cerebral infarction and predictive value of illness.Methods A total of 110 patients with acute cerebral infarction in the hospital from September 2015 to November 2016 were selected as the research object and grouped according to the state of the illness before treatment,infraction size:38 cases were less than 5 cm~3,38 cases were between 5-10 cm~3,and 34 cases were more than 10 cm~3.47 cases were mild,43 cases were moderate and 30 cases were severe.The levels of ADPN,hs-CRP and IL-6 were determined before treatment,one week after treatment and one month after treatment by MESSS assessment.Simultaneously,46 participants,who took physical examination,were selected as healthy control group to detect the levels of ADPN,hs-CRP and IL-6.The levels of ADPN,hs-CRP and IL-6 in all the group were compared,the dynamic changes serum ADPN,hs-CRP and IL-6 of the patients with acute cerebral infarction after treatment,and the correlation analysis was conducted on serum ADPN,hs-CRP and IL-6 by MESS.Results The serum ADPN level of patients with cerebral infarction was significantly lower than that of the healthy control group,and the levels of hs-CRP and IL-6 were significantly higher than those of the healthy control group,with statistically significant difference(P0.05).The serum ADPN levels dropped and the levels of hs-CRP and IL-6 increased with the increase of infraction size and severity of illness,the difference showed statistical significance(P0.05).The levels of hs-CRP and IL-6 in the acute cerebral infarction group were significantly higher than those in the control group before treatment,one week after treatment and one month after treatment,while the levels of serum ADPN in the acute cerebral infarction group were obviously lower than that in the healthy control group one week after treatment,and higher than that in the healthy control group one month after treatment,the difference had statistical significance(P0.05).There was a negative correlation between MESSS and ADPN,(r=-0.367,P0.05)and there was a positive correlation between MESSS and hs-CRP and IL-6(r=0.239,0.217,P0.05).Conclusion Serum ADPN,hs-CRP and IL-6 can reflect the state of the acute cerebral infarction and dynamic changes,with predictive value for the development of disease.
【CateGory Index】: R446.1;R743.3
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Giuseppe Maiolino;Valeria Bisogni;Giacomo Rossitto;Gian Paolo Rossi;Department of Medicine - DIMED, Hypertension Clinic, University of Padua;;Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications[J];World Journal of Cardiology;2015-10
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Wang Kun;Zhao Changxin;Zhang Ying;Yang Fumeng;Jiang Jiandong;Cao Jinxia;Zhang Tinglu;Department of Clinical Laboratory,the Second Peoples Hospital of Lianyungang;Emergency Office,the Center for Disease Control and Prevention of Lianyungang;;The clinical value of combined detection of plasma Lp-PLA_2 and D-dimer in patients with hypertension complicated with stroke[J];中国基层医药;2017-04
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