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《International Journal of Laboratory Medicine》 2019-10
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Effect of irbesartan combined with atorvastatin calcium on the serum level of ox-LDL,hcy in the early treatment of diabetic nephropathy

CHEN Hailan;Kidney Department of Endocrinology,Chinese People′s Liberation Army 266 Hospital;  
Objective To investigate the clinical effect of irbesartan combined with atorvastatin calcium on the levels of serum glucose,lipid,renal function,oxidized low-density lipoprotein(ox-LDL)and hemocysteine(hcy)in the early treatment of diabetic nephropathy(DN).Methods A total of 160 DN patients with typeⅡdiabetes in the hospital were enrolled and divided into group A,group B,group C and group D at random,40 cases in each group.The patients in the group A adopted traditional treatment,the group B with irbesartan,the group C with atorvastatin calcium,and the group D with irbesartan combined with atorvastatin calcium.The levels of serum glucose,lipid,renal function and ox-LDL,hcy levels were detected and compared among the four groups.Results After 2-month treatment,the levels of serum glucose,lipid,renal function,ox-LDL and hcy in the four groups were improved than those before treatment,and the levels of serum glucose,lipid BUN,UALB/Cr,ox-LDL and hcy in the group D were lower than those in the other three groups,while the value of eGFR was higher than that in the other three groups,the difference had statistically significant difference(P0.05).The reduction of the levels of serum ox-LDL and hcy was independent factors of the clinical effect of irbesartan combined with atorvastatin calcium on early DN patients.Conclusion The application of irbesartan combined with atorvastatin calcium in early treatment of diabetic nephropathy could effectively improve the renal function and decrase the serum levels of ox-LDL and hcy,and the application is worthy of clinical promotion.
【Fund】: 承德市科学技术研究与发展计划项目(201606A090)
【CateGory Index】: R587.2;R692.9
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1 XU Honglan;WAN Meiyan;XIA Ping;ZOU Zuojun;Department of Nephrology,Qingdao Municipal Hospital;;Clinical value of serum ox-LDL detection in patients with diabetic nephropathy[J];实用临床医药杂志;2015-03
2 LI Sheng-bing1,TANG Shi-guo2(1.Department of Endocrinology,the Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China;2.Department of Endocrinology,Chongqing Ninth People′s Hospital,Chongqing 400700,China);Therapeutic effect of combination of beraprost sodium with irbesartan on diabetic nephropathy[J];检验医学与临床;2012-15
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1 XUE Songyan1,JIANG Hongwei2*,ZHANG Xiaoju1,YAO Rui1,YUAN Ping1,REN Dezhi3,LI Feng1#(1Dept of Traditional Chinese Medicine,Xijing Hospital of Fourth Military University,Xi'an 710032,China;2Institute of Integrative Medecine,Shaanxi Provincial People's Hospital;3Dept of Heart Disease,Shaanxi Provincial Traditional Chinese Medicine Hospital);Clinical efficacy of Xueshuantong injection combined with benazepril for diabetic nephropathy[J];山西医科大学学报;2013-03
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