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《International Journal of Laboratory Medicine》 2019-10
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Research advancement on the correlation between intestinal flora and chronic kidney disease

ZHANG Yuzi;LI Minmin;Inspection Center,Clinical Medicine,the First Affiliated Hospital of Jinan University;  
With the application of hig-throughput sequencing in the field of microbiology,an increasing evidence suggests that the gut microbiota is closely related to the pathogenesis of chronic kidney disease(CKD).The pathological state of CKD can induce changes in the composition and function of the gut microbiome,that lead to generation of multiple enterogenous uremic toxins(UTs)and dysfunction of intestinal barrier.These toxins translocate into circulation stimulated systemic inflammation and increased cardiovascular risk.This review focus on the research status and related mechanisms of the microbiome in CKD pathogenesis,in the hope to provide new help for delaying the persistent progression.
【Fund】: 广东省新药筛选重点实验室开放基金项目(GDKLNDS-2018OF003)
【CateGory Index】: R692
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