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《International Journal of Genetics》 2006-01
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Influence of Toll-Like Receptor 4 Mutation in Induction and Progression of Acute Lung Injury

ZHANG Jin-xiang~1,WANG Hui~2,XU Jian-bo~3,JIANG Chun-fang~1,WU He-shui~3,ZHENG Qi-chang~4.(~1Department of Emergency Surgery,Union Hospital Affiliated to Huazhong University of Science and Technology,Wuhan 430022;~2Medical Biology Department,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022;~3Pancreatic Disease Centre,Union Hospital Affiliated to Huazhong University of Science and Technology,Wuhan 430022;~4Hepatobilliary Surgery Department,Union Hospital Affiliated to Huazhong University of Science and Technology,Wuhan 430022,P.R.China)Corresponding author: ZHANG Jin-xiang.E-mail: camelzjx@yahoo.com.cn  
Objective To observe the difference in lung injury between toll-like receptor 4(TLR4) mutant mice and wild type mice in a model of hypovolemic shock resuscitation plus lipopolysaccharide(LPS) attack induced acute lung injury(ALI).Methods A mouse model of hypovolemic shock resuscitation plus different doses of LPS attack induced ALI was reproduced in both TLR4 mutant(TLR4~(-/-)) and wild type(WT,TLR4~(+/+)) mice.ALI was estimated by the values of wet weight/dry weight ratio(W/D) and lung permeability index(LPI) of lung tissues.The levels of myeloperoxidase(MPO) in both strains were assessed the extent of polymorphnuclear neutrophils(PMN) infiltration in lung tissues.And the levels of tumor necrosis factor-α(TNF-α) and interleukin-1 beta(IL-1β) were detected as well.Results The injury of lung tissues was milder in TLR4 mutant mice than that in wild type mice as indexed by the value of W/D and LPI.In the model of hypovolemic shock resuscitation plus different doses of LPS attack induced ALI,the extent of lung edema(W/D) in TLR4 mutant mice was reduced compared with that in wild type mice,especially in 5mg·kg~(-1) group.Conclusion TLR4 takes part,at least partially,in the development of ALI via release of cytokines and sequestration of PMN into lung tissues.
【Fund】: 湖北省自然科学基金资助(No.2005ABA162)
【CateGory Index】: R363
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