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《International Journal of Genetics》 2006-01
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Pathogenesis of Primary Hyperuricemia

CHEN Ying,LI Chang-gui,MIAO Zhi-min.(Department of Endocrine,the Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,P.R.China)Corresponding author: CHEN Ying.E-mail: qdchenying@yahoo.com.cn  
Since the prevalence of gout and hyperuricemia increases every year,hyperuricemia has close correlation with metabolic syndrome(insulin-resist syndrome),more and more researches focus on the pathogenesis of hyperuricemia.Hyperuricemia may be the consequence of increased uric acid production and/or decreased renal capacity to excrete uric acid.Long-lasting hyperuricemia may cause gout and is associated with hypertension,obesity,diabetes,vascular disease,renal disease and cardiovascular events.In this article,we discuss the recent findings in the pathogenesis of primary hyperuricemia.
【Fund】: 国家自然科学基金资助项目(No.30470821)
【CateGory Index】: R589.7
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