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《International Journal of Genetics》 2006-01
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The Studies on the Polymorphisms of Candidate Genes Responsible for the Graves' Disease

SUN Ling-(ling~(1,2,3)),WANG Yi~1,HUANG Wei~(1,2).(~1Chinese National Human Genome Center at Shanghai,Shanghai 201203;~2Ruijin Hospital,Shanghai,Jiao Tong University Medical School,Shanghai 200025;~3Department of Biochemistry,Wannan Medical College,Wuhu 241001,P.R.China)Corresponding Author: SUN Ling-ling.E-mail: sunll@chgc.sh.cn  
Graves' disease(GD) is an organ-specific autoimmune disorder.The etiology of GD is very complex,which is speculated as the results of interaction of heredity and environment.Recently,with the development of the studies on human genome sequences and SNPs,great progress has been made for the identification of the susceptible genes of complex diseases.The high throughout genetic analysis of the candidate genes plays an important role in discovering the mechanisms of the diseases.Currently,many researches of the candidate genes of GD have focused on the genes that may be linked with disease pathology or thyroid-specific genes,such as HLA-Ⅱ,TNF,CTLA-4,CD40,Interleukins,TSH-R,TG etc..Here,we offer a review of the studies of the polymorphisms of these genes and their association with the Graves' disease.
【Fund】: 国家“863”科技攻关计划(No.2002BA711A10)
【CateGory Index】: R581
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Chinese Journal Full-text Database 10 Hits
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