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《International Journal of Genetics》 2007-06
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Identification of a Ring Chromosome 13 Combined with Terminal Rearrangement of Chromosome 6 and Genetic Counseling

TAN Yu-mei~1 TAN Yue-qiu~2 XU Xiao-qing~1 SONG Dan~1 WU Fang-gui~1 QIAN Wei.ping~(1,2) (1 Reproductive Centre of People's Hospital of Sheazhen Luohu,Shenzhen 518001;2 Institute of Reproduction and Stem Cell Engineering,Central South University,Changsha 410078,China)  
Objective To determine the karyotype of a case with ring chromosome 13 and chromosome 6 terminal rearrangement,and provide a valuable guidance for pregnancy.Methods Fluorescence in situ hybridization(FISH)with a whole chromosome 6 specific painting probe and a whole chromosome 13 specific painting probe,were used to lanalyze a case with history of pregnancy of deformation child and ring chromosome and 6p addition detected by conventional G banding technique.Results The patient's karyotype is ring chromosome 13,combination with terminal rearrangement between chromosome 13q distant segment and chromosome 6 terminal segment.Conclusion The karyotype is a uniusual structural rearrangement,which is originalted from three-breakage.According to the rule of gametes production by meiosis,the patient has the probability of giving birth to a normal child,but must carry out prenatal diagnosis to obtain a normal child.
【CateGory Index】: R394
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 TAN Yue Qiu, LI Lu Yun, LU Guang Xiu ① (Human Reproductive Engineering Laboratory, Xiang Ya School of Medicine,Central South University, Changsha 410078, China);Molecular Cytogenetic Detection of Minute Chromosomal Structural Abnormality on the Chromosomal Terminal Regions[J];Acta Genetica Sinica;2002-09
2 QIAN Wei-Ping~(1,2),TAN Yu-Mei~2,TAN Yue-Qiu~1,SONG Dan~2,XU Xiao-Qing~2,LI Lu-Yun~1,LU Guang-Xiu~1(1.Institute of Reproduction and Stem Cell Engineering,Xiangya School of Medicine,Central SouthUniversity,Changsha 410078,China;2.People's Hospital of Luohu District of Shenzhen,Shenzhen 518001,China);Minute Chromosome Rearrangement Detected by Human Telomeric Band Painting Probes[J];Hereditas;2006-05
3 LIANG De-sheng, WU Ling-qian, LONG Zhi-gao, PAN Qian, DAI He-ping, XIA Jia-hui. (National Laboratory of Medical Genetics, Central South University, Changsha, Hunan, 410078 P.R.China. );Chromosome analysis and phenotype location analysis on a patient with the karyotype of 45,XX,-13/46,XX,r(13)/46,XX,r(13;13)/47,XX,2r(13)(p13q32.3)[J];Chinese Journal of Medical Genetics;2004-04
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 DIAO Ying ( Key Laboratory of MOE for Developmental Biology, Wuhan University; Biology Department, West Chongqing University,Yongchuan Chongqing 402168 Lotus Research Center, Wuhan University, Wuhan 430072, China);A Study of the FISH Protocol on Lotus Chromosomes[J];Amino Acids & Biotic Resources;2004-02
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 Huang Haojie;Zhang Xiran; Chen Yifeng(Nanjing Normal University Nanjing 210097)Cui Yingxia(Nanjing Miliary General Hospital. Nanjing 210002);A Study on Complicated Chromosome Translocation by Fluorescence in situ Hybridization(FISH)of G-banded Chromosomes[J];ACTA GENETICA SINICA;1996-05
2 TAN Yueqiu, LI Xiurong, LI Luyun, LU Guangxiu. (Human Reproductive Engineering Laboratory, Xiangya Medical College of Central South University, Changsha, Hunan 410078 P. R. China. );Study of a familial insertional translocation involving chromosomes 1 and 7 by using fluorescence in situ hybridization[J];Chinese Journal of Medical Genetics;2001-03
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