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《Drugs & Clinic》 2014-01
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Protection of flavonoid components baicalein,quercetin,or sodium danshensu on cytotoxicity and cellular DNA damage induced by cigarette smoke

CHEN Hong-jun;GAN Zhi-bin;LIU Xia;YU Zi-cheng;FENG Yi-shan;LU Jian-zhong;Institute of Clinical Pharmacy and Pharmacology, Tongji University School of Medicine;Department of Pharmaceutical Analysis, School of Pharmacy, Fudan University;  
Objective To evaluate the protective effect of flavonoid components baicalein, quercetin or sodium danshensu on cytotoxicity and cellular DNA damage induced by cigarette smoke. Methods Two kinds of eukaryotic cells B-16 cells and oral buccal mucosal cells in liquid were attacked by the mainstream smoke produced via on-line cigarette smoking according to FTC with or without baicalein, quercetin or sodium danshensu. The cytotoxicity and cellular DNA damage were respectively assessed by MTT method and single cell gel electrophoresis. Results The cytotoxicity of B-16 cells and DNA damage of two kinds of cells induced by on-line cigarette smoking were obvious. A positive relationship was observed between the exposure time in smoke and the tail moment and olive tail moment of comet cells. Baicalein, quercetin, or sodium danshensu(1 mmol/L) could relieve the cytotoxicity by about 50% and decrease the DNA damage by more than 60%. Conclusion There is a positive relationship between the exposure of cells in smoke and the cellular DNA damage, and the flavonoid components baicalein, quercetin, or sodium danshensu have a protective effect against the genotoxicity of cigarette smoke.
【Fund】: 国家自然科学基金资助项目(81302741)
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 10 Hits
1 GAO Jian-jun,FENG Sheng-mei,JIN Wei-fang (Bone Metabolism Department,Institute of Radiation Medicine,Fudan University,Shanghai 200032,China);Improvement of Gel Preparation on Alkali Single Cell Gel Electrophoresis[J];Journal of Shanghai Medica(University);2004-03
2 SHEN Liang1,JI Hong-fang1,CHAI Jian-guo2,ZHANG Shan-fei2,ZHANG Hong-yu1(1.Shandong Provincial Research Center for Bioinformatic Engineering and Technique,Shandong University of Technology,Zibo 255049,China;2.Chiatai Qingchunbao Pharmaceutical Co.Ltd.Hangzhou 310023,China);THEORETICAL EVALUATION ON RADICAL-SCAVENGING ACTIVITY OF NINE NATURAL PRODUCTS[J];Acta Biophysica Sinica;2005-05
3 Wang Shuo1,2,3,Wang Zhenjie4,Zhao Feng1,2,3(1.TCM Clinical Medical Science College of China Three Gorges University,Yichang 443000,Hubei,China;2.The TCM Hospital of Yichang City,Yichang 443000,Hubei,China;3.The Affiliated Yichang Hospital of Hubei University of Chinese Medicine,Yichang 443000,Hubei,China;4.The People's Hospital of Puyang City,Puyang 457000,Henan,China);Experimental study on protective effects of tanshinol on oxidative stress injured vascular endothelial cell[J];Modern Journal of Integrated Traditional Chinese and Western Medicine;2011-20
4 JIN Shun ji 1, DUAN Lian 1, HUANG Mei 1, YANG Jing yu 1, YU Hai 1, ZHAO Yu qing 2, WU Chun fu 1 (1 Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China; 2. Research Center of New Drug, Liaoning College of TCM, Shenyang 110000, China);Protective effect of resveratrol and ascorbic acid on lymphocyte DNA damage in mice induced by prescriptions Ⅰ and Ⅵ of Chinese materia medica against SARS[J];Chinese Traditional and Herbal Drugs;2003-12
5 WANG Hong, LIU Qiong, ALI Abdella, XU Hui-bi (Institute of Pharmacy, Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China);Antagonistic effect of scutellarin on toxicity of selenium in human liver cells L-02[J];Chinese Traditional and Herbal Drugs;2004-04
6 SHEN Zhi-hua1,JIE Wei2,CHEN Jin1,HUANG Pei-chun1(1.Department of Pathophysiology,Guangdong Medical College,Zhanjiang 524023,China;2.Department of Pathology,Guangdong Medical College,Zhanjiang 524023,China);Effects of matrine on proliferation and metastasis abilities of human ovarian carcinoma HO-8910PM cells line[J];Chinese Traditional and Herbal Drugs;2008-03
7 WAN Gui-ping,ZHANG Zhen-zhen,CAI Xue-ting,LU Wu-guang,CAO Peng Laboratory of Cellular and Molecular Biology,Jiangsu Province Acacemy of Traditional Chinese Medicine,Nanjing 210028,China;Mechanism of escin sodium in inhibition of human leukemia Jurkat cells proliferation[J];Chinese Traditional and Herbal Drugs;2012-01
8 WANGQi′en ,QULu ,HANChunhua ,etal. DepartmentofOccupationalHealth ,BeijingMedical University,Beijing ,10 0 0 83 ,China;Effect of chrysotile and cigarette smoking solution on DNA damage and repair in human alveolar epithelial cells[J];CHINESE JOURNAL OF PREVENTIVE MEDICINE;2000-01
9 ZOU Ya-ling,LAI Rui-ping,ZHOU Li-hong,LI Xiao-yan,LU Wen-qing.Department of Occupational and Environmental Health and MOE Key Laboratory of Environment and Health,School of Public Health,Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430030,China;Enhancement effect of polychlorinated biphenyl on benzo(a)pyrene-induced DNA damage in HepG2 cells[J];Chinese Journal of Preventive Medicine;2006-02
10 CHEN Hong-jun1,LIU Xia1,YU Zi-cheng1,GAN Zhi-bin1,QIU Jin1,LU Jian-zhong2(1.Institute of Clinical Pharmacy and Pharmacology,Yangpu Hospital of Tongji University of Medicine,Shanghai 200090;2.School of Pharmacy,Fudan University,Shanghai 201203);Active flavanoids protect plasmid DNA damage induced by cigarette smoking[J];Central South Pharmacy;2013-07
Chinese Journal Full-text Database 10 Hits
1 DUAN Lian,ZHANG Hong-wei(Institute for Environmental Health and Related Product Safety,CDC,Beijing 100050,China);Inhibitory Effect of Vitamin C on Mice Lymphocyte DNA Damage Induced by Organic Extracts from Water[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-03
2 JIA Zheng et al (Key Laboratory for Science and Technology of Urban Residential Environment,Shenzhen Graduate School,Peking University,Shenzhen,Guangdong 518055);Extraction of Flavonoids from Eucommia ulmoides Leaves by Ultrasonic and Research on Its Antioxidation[J];Journal of Anhui Agricultural Sciences;2008-04
3 MA Chao,HAO Qing-nan,MA Bing-gang(Agricultural College,Shihezi University,Shihezi,Xinjiang 832003,China);Separation and Determination of Resveratrol and Its Pharmacological Functions[J];Northern Horticulture;2008-04
4 ZHANG Li-ping,YU Xiao-qin(Dyeing and Finishing Department,Chengdu Textile College,Chengdu 610023);Application of Microwave Extraction Technology in Flavonoids[J];Journal of Chengdu Textile College;2006-03
5 Li Jun,Si Weike,Zhao Chen,Li Zhaoquan,Pan Jing (Department of Clinical Hematology,College of Medical Laboratory,Third Military Medical University,Chongqing 400038,China);Study on the effect of MA and OM on tumor growth and their immunoregulatory function in tumor bearing mice[J];Chongqing Medicine;2011-27
6 MA Ning,Wang Jianfen,Xu Fang,Li Yuan,Li Juan Changsha medical college,Changsha,410219,China;Reviews of reseaches on resveratrol[J];Journal of Changsha Medical College;2009-01
7 Chen Naidong,Hu Jinrong,Zhou Shoubiao~*,Luo Qi,Wang Guijun(Key Lab.of Biological Resources Conservation and Utilization of Anhui Province, College of Life Science,Anhui Normal University,Wuhu 241000,China);Flavone extraction technology from Lespedeza dunnii and the measurement of its antioxidant ability[J];Forest By-Product and Speciality in China;2006-05
8 Zheng Hequan,Zhou Shoubiao*,Zhu Xiaofeng,Liu Kun,Liu Shoufeng(Key Laboratory of Biological Resources Conservation and Utilization, College of Life Science,Anhui Normal University,Wuhu Anhui 241000,China);Ultrasonic Assisted Extraction of Total Flavone From Iris ensata[J];Forest By-Product and Speciality in China;2008-04
9 LEI Chun-yan1,SHEN Xiu-hua2,ZHANG Nai-ning1,CONG Feng-song3,MA Li-jun4,SONG Li-hua1,5 1.Department of Food Science and Engineering,School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai 200240,China 2.Department of Nutrition,School of Medicine,Shanghai Jiaotong University,Shanghai 200025,China 3.Experimental Teaching Center,School of Life Science and Technology,Shanghai Jiaotong University,Shanghai 200240,China 4.Department of Oncology,Changning Branch,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200050,China 5.Bor S.Luh Food Safety Research Center,Shanghai Jiaotong University,Shanghai 200240,China;Effects of genistein on proliferation and DNA damage of irradiated human liver L-02 cells[J];Academic Journal of Second Military Medical University;2012-04
10 Xu Qingfang Lin Nengqiang Zhang Ling Liu Suping Wu Ruojing(College of Life Sciences,Fujian Normal University,Fuzhou 350108,China);Cigarette smoke right mouse bone marrow erythrocytes injury[J];Fujian Journal of Animal Husbandry and Veterinary Medicine;2008-02
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 CAO Yi, CHEN Rui, WANG Zhong_wen, et al(China Institute for Radiation Protection,Taiyuan 030006, China);MEASUREMENT OF DNA DAMAGES INDUCED BY RADIATION AND CHEMICALS USING COMET ASSAY[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-03
2 DONG Jie-ying 1 ,LOU Zhe-feng 1 ,ZHENG Zhong 2 ,et al (1.Department of Biology,Wenzhou Medical College,Wenzhou325035,China;2.Class of2000laboratory science,Wenzhou Medical College,Wenzhou325035,China);Use of the Single Cell Gel Electrophoresis/Comet Assay for Detecting the DNA Damage Effect of Formaldehyde to Mouse Testicular Cell in Vivo and in Vitro[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-03
3 LIU Yan-jun, LIN Zhe-xuan, LI Hui, et al(The Center Laboratory, Shantou UniversityMedical College, Shantou 515041, China);DNA Damage of Human Umbilical Vein Endothelial Cells Caused by Formaldehyde and H_2O_2 with Comet Assay and K-SDS Assay[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-01
4 Gou Xin Min1, Chen Yan1, Chen Xiao Yi1, John R Arrand2$$$$1.Department of Pathology, Guangdong Medical College, Zhanjiang, Guangdong, 524023, P.R.China 2.Institute for Cancer Studies, University of Birmingham, Vincent Drive, Birmingham B15 2TT, UK;Effects of Epstein-Barr Virus Latent Membrane Protein1(EBV-LMP1) on Related Factors of Metastasis of Nasopharyngeal Carcinoma Cell Line CNE1[J];Chinese Journal of Cancer;2003-05
5 HE Hai Yan YANG Dong Ni QIAN Cheng YUAN Hong Sheng SUN Jiu Rong (College of Lifescience, Peking University, Beijing 100871, China);EFFECTS OF FLAVONOID OF GINKGO BILOBA ON THE FUNCTIONAL CHANGES FOLLOWING BRAIN INJURY IN RATS[J];Acta Zoologica Sinica;2002-02
6 LIANG Bing,YANG Ai-fu,HUANG Feng-lan,HU Bao-zhong(College of Life Science,Northeast Agricultural University,Harbin Heilongjiang 150030,PRC);Research advances on chemical constituents and pharmacological activities in Glycyrrhiza[J];Journal of Northeast Agricultural University;2006-01
7 LI Chuan-xun,ZHOU Qin,GAO Guang-you, et al (Department of Pharmacology,Dalian Medical University,Dalian 116027,China);Effects of Ginkgoliloba leave flavonoids on blood lipid level in high lipid rats[J];Journal of Dalian Medical University;2001-03
8 LIU Ying shuai, LU Zhi song, YANG Ji wen, WU Lian feng, YANG Xu College of Life Science, Central China Normal University, Wuhan 430079, China;Quantification Study on the DNA-protein Crosslinks of Human Blood Lymphocytes Induced by Formaldehyde[J];Hubei Journal of Preventive Medicine;2004-04
9 ZHANG Junning 1 HONG Chengjiao 2 ZHU Shoupeng 2 1(Suzhou University First Affiliated Hospital, Suzhou 215006) 2(Nuclear Medical College, Suzhou University, Suzhou 215007);DNA SINGLE AND DOUBLE STRAND BREAKS OF PERIPHERAL BLOOD LYMPHOCYTES IN MICE INDUCED BY γ RAYS IRRADIATION[J];Journal of Radiation Research and Radiation Processing;2002-03
10 XIANG Guang-ya, HAO Qiao-ling, YUAN Jin-wei, ZHOU Yi-kai (Institute of Enviromental Medicine of Tongji Medical College, Central China University of Sciences and Technologies, Wuhan, Hubei 430030);Studies on Effect of Hypericum Chinense on Eliminating Active Oxy-radical[J];Academic Journal of Guangdong College of Pharmacy;2000-04
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