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《Journal of Guangxi Normal University(Natural Science Edition)》 2016-01
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Chronic Stress Affects the Theta Activity in BLA to Induce the Stress Response in Mice

JIANG Fangjie;FU Yu;WU Guisheng;YANG Liping;TANG He;DENG Ke;LIN Wanhua;LUO Huairong;State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences;University of Chinese Academy of Sciences;Kunming University of Science and Technology;Yunnan Institute of Traditional Chinese Medicine and Materia Medica;College of Life Science,Guangxi Normal University;  
Chronic exposure to stress triggered many dysfunctional emotional behaviors,like generalized anxiety disorder,depression and bipolar disorder.Prolonged stress led to structural changes in the prefrontal cortex-amygdala-ventral hippocampus emotional circuit and thus exerted anxiety behavioral phenotypes.But the alteration of neural activity for those nucleus that involved in emotional regulation is not clear.So chronic stress model in mice was established local field potential(LFP)were recorded from the basolateral amygdala(BLA)and hippocampal CA3 respectively in freely exploring mouse and separated the signals into alpha,beta,and delta,theta,gamma frequency bands.In contrast to the control groups,in BLA,stress induced a trend of increase of LFP absolute power at these five bands,the increase at delta band was significant.Through further analysis of the LFP relative power,it showed that there was a distinct increase at delta band and a significant decrease at theta band in stressed mice.
【Fund】: 国家自然科学基金资助项目(81370453);; 云南省自然科学基金资助项目(2012FB181);; 云南省重点新产品开发计划项目基金资助(2014BC011)
【CateGory Index】: R749.72
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