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《Journal of Guangxi Normal University(Natural Science Edition)》 2016-01
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Effects of Glycyrrhiza Flavonoids on Lipid Metabolism Enzyme and Expression of ERRαmRNA and Protein of Exhaustive Rats

HUANG Dong;LI Yuelin;BU Kai;HUANG Wen;MO Weibin;Sport School of Guangxi Normal University;State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources,Ministry of Science and Technology of China;  
In order to explore the intervention effect of endurance training of fat Rats on the lipid metabolism enzyme,Expression of ERRa mRNA and Protein and the complementary licorice flavonoids.Fifty healty male Sprague-Dawley rats were Randomly chosen for groups,each consisting of 10rats:the quiet control group(NC),the exercise group(NE),the administration of licoflavone in low dose exercising group(GFML,4g·kg~(-1)·d~(-1)),the administration of licoflavone in middle dose exercising group(GFME,8g·kg~(-1)·d~(-1))and the administration of licoflavone in high dose exercising group(GFMH,12g·kg~(-1)·d~(-1)).After the rats in control group were administrated of pure physiological saline at the same dose,the rats were killed after 6-week training.According to the kit method of determination of on lipid metabolism enzyme(HL,LPL,ApoCⅡand ApoCⅢ)in serum of rats and Expression of ERRa mRNA and Protein and The HL content in the quiet control group is lower than that of the exercise group((P0.05),The content of HL in GFM was higher than that of in the exercise group((P0.05).The content of LPL was higher than that of the quiet control group(P0.05),The content of LPL in GFM was higher than that of the quiet control group and the exercise group.The content of ApoCⅡin the exercise group was higher than that of the quiet control(P0.05),The content of ApoCⅡin GFM,compared with the quiet control group is significantly different(P0.05 or P0.01),The content of ApoCⅢ is lower than that of the quiet control group(P0.05),which means there are significantly different between GFME and GFMH and the quiet control group(P0.05).The Adipose tissue Expression of ERR mRNA and Protein in NE was higher than that of the NC(P0.05).The Adipose tissue Expression of ERR mRNA and Protein was higher than that of the NC and NE(P0.05 or P0.01).Supplement of glycyrrhiza flavonoids can improve blood lipid metabolism and regulate enzyme levels in the body of relative stability so as to prevent lipid metabolic disorder.
【Fund】: 国家自然科学基金资助项目(31460232 21562006);; 广西高校科研项目(YB2014384);; “药用资源化学与药物分子工程教育部重点实验室”开放课题(CMEMR2012-B04);; 广西研究生创新项目(YCSW2015084)
【CateGory Index】: R285.5
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