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《Journal of Guangxi Normal University(Natural Science Edition)》 2018-04
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Protective Effect of Magnesium-L-Threonate on Dopamine Neurons and Its Mechanism

LUO Raoshan;SHEN Yanling;SUN Liyuan;Guangxi Key Laboratory of Brain and Cognitive Neuroscience;Department of Pathology,Affiliated Hospital of Guilin Medical University;Successful Affiliated Hospital of Xiamen University;  
To evaluate the neuroprotective effect of Magnesium-L-threonate(MgT)on mice model of Parkinson's disease(PD)induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)and to investigate the possible mechanism.The PD mice model was established.The mice were randomly divided into control group,MPTP group and the MPTP+MgT group.Rotary bar method was used to observe behavioral changes in mice.The number of dopaminergic neurons in substantia nigra was observed by TH staining.The expression of GFAP,iNOS and TH in substantia nigra and striatum were detected by Western blotting.The time for the MPTP+ MgT group to stay on the rotating rod was68.07%longer than that in the MPTP group.The results showed that,in MPTP+MgT group,the number of dopamine neurons in the substantia nigra increased by 46.15%than that in the MPTP group.Compared with MPTP group,the expression of GFAP and iNOS in MPTP+ MgT group was statistically significant(P0.05).The mechanism of MgT neuroprotective effect is probably related to the down-regulation of GFAP and iNOS expression,and inhibition of inflammation and oxidative stress.
【Fund】: 国家自然科学基金(81260205);; 广西自然科学基金(2015GXNSFAA139137)
【CateGory Index】: R742.5
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