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《Acta Optica Sinica》 2008-07
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Image Reconstruction in Fluorescence Molecular Tomography Based on Full Time-Resolved Scheme

Zhang Limin He Huiyuan Gao Feng Zhao Huijuan(College of Precision Instrument and Optoelectronics Engineering,Tianjin University,Tianjin 300072,China)  
In fluorescence molecular tomography(FMT),the time-resolved(TR) measurement can provide the richest information on photon migration.A full time-resolved scheme is extended to time-domain fluorescence molecular tomography,based on the finite element-finite time difference diffusion equation in forward model and the Newtown-Raphson inversion method.The abilities of spatial resolution,quantitativenesss,discerning the differences in target size,grayscale resolution and noise robustness are validated by using simulated data.The proposed method is demonstrated with the capability of simultaneously recovering the fluorescent yield and lifetime.Compared with the generalized pulse spectrum technique for reconstructing images,it shows its superiority in almost every aspect.
【Fund】: 国家973计划(2006CB705700);; 国家自然科学基金(60578008 60678049);; 天津市自然科学基金(07JCYBJC06600)资助课题
【CateGory Index】: TP391.41
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