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《China Medicine and Pharmacy》 2017-15
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Effect of serum MK and Th17 and regulatory T cell on the occurrence and development of patients with rheumatoid arthritis

SHEN Cong;LIU Chanjuan;SUN Yuqi;YU Qi;Department of Clinical Laboratory, the Second Affiliated Hospital of Mudanjiang Medical University;  
Objective To explore the effect of immune imbalance of T helper cell 17(Th17) and regulatory T cell(Terg) on attack of patients with rheumatoid arthritis and to explore the effect of serum midkine(MK), Th17 and regulatory T cell on the occurrence and development of patients with rheumatoid arthritis. Methods 58 patients with rheumatoid arthritis who were admitted to our hospital from March 2013 to January 2016 were selected. They were divided into the active group(DAS28 3.2) and the inactive group(DAS28≤3.2). Other 30 healthy people were selected as the control group. There were 32 cases in the active group and 26 cases in the inactive group. Levels of serum MK, Interleukin-17(IL-17), Interleukin-6(IL-6) and Interleukin-23(IL-23) were detected by enzyme linked immunosorbent assay. Changes of ratio of regulatory T cell and peripheral blood(Th17) were detected by flow cytometry. In addition, changes of ratio and levels of MK, IL-17, IL-6 and IL-23 were compared. Results Th17 and regulatory T cell ratio in the active group and the inactive group had respectively comparative difference and the difference was statistically significant(P 0.05). The active group and the inactive group had respectively comparative differences with the control group in Th17 and regulatory T cell ratio and differences were statistically significant(P 0.05). Levels of IL-17, IL-6 and IL-23 of the active group and the inactive group had respectively comparative differences with the control group and differences were statistically significant(P 0.05). Percentage of serum MK and Th17, percentage of serum MK and T cell and results of correlation related to balance showed that Th17 and Terg were both had no relation with serum MK, P 0.05 while they were negatively correlated with STAT5(P 0.05). Conclusion Serum MK of patients with rheumatoid arthritis increases, Th17 in balance of Th17 and Terg relatively increase and Terg relatively decreases. Increase of MK and imbalance of Th17 and Terg both promote the occurrence and development of RA.
【CateGory Index】: R593.22
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