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《China Medicine and Pharmacy》 2017-15
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Clinical study on the time of interventional therapy for acute severe pancreatitis with peritoneal lavage with pigtail tube

WU Benhua;ZHOU Yingsheng;LEI Pingguang;Guangming New District People's Hospital Shenzhen;Songgang People's Hospital Shenzhen;  
Objective To explore the time of interventional therapy for acute severe pancreatitis with peritoneal lavage with pigtail tube. Methods Retrospective cohort study method was used.60 patients with severe acute pancreatitis cured in our hospital grom March 2014 to October 2016 were selected as the study object.On the basis of general conservative treatment,the pig tail tube was used for abdominal lavage.They were divided into group A,group B and group C,according to the timing of intervention(24h,48 h,72h),with 20 patients in each group.According to B ultrasonic examination,peritoneal effusion was divided into group D and group E.The C reactive protein(CRP),APACHE,II,neutrophil count(NEU),systemic inflammatory response syndrome(SIRS)duration,and the number of consecutive renal replacement therapy(CRRT)cases and deaths were used as observation indicators. Results There were no statistical significance on CRP value,APACHE,II value,and NEU between the three groups.On the 7d after treatment,the CRP value,APACHE,II value,NEU of group A,group B and group C were lower than before treatment,there were significant differences(P 0.01),and there were differences between groups(P 0.05).With the delay of peritoneal lavage treatment,the decrease of CRP,APACHE,II and NEU decreased(P 0.05).There were no deaths in group A,group B and group C.The duration of SIRS and the number of CRRT cases were compared(P 0.05).In group D,ascites was detected by ultrasonography,and there were 35 cases.The E group had no peritoneal effusion after B ultrasonic examination,and there were 25 cases.There were differences in the intra abdominal pressure before and after treatment in group D and group E(P 0.05).In group D and group E,on the 7D after treatment,intraperitoneal pressure decreased significantly,compared with before treatment(P 0.01),and there were differences between groups(P 0.05). Conclusion Different pig tail tubes,peritoneal lavage,interventional timing in the treatment of severe acute pancreatitis have different effects.If the ultrasound examination shows peritoneal effusion,within 24 hours of the tube peritoneal lavage therapy is the best time to intervene with pig tail.
【Fund】: 广东省深圳市宝安区科技计划项目(2014237)
【CateGory Index】: R576
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