Investigation of liver injury in antituberculosis treatment of tuberculosis complicated with HIV/AIDS
TAN Jianming;JI Qiuping;LIAO Xiaoyun;LIU Yu;LIU Baozhen;Department of Respiratory Medicine, Maoming Chronic Disease Prevention and Treatment Center;
Objective To explore the effects of antituberculosis therapy on liver injury in patients with tuberculosis complicated with HIV/AIDS. Methods The clinical data were collected from 384 patients with TB treated in our hospital from January 2014 to January 2017. All patients were subjected to enzyme-linked immunosorbent assay(ELISA) to detect human immunodeficiency virus(HIV) antibodies. 65 patients with HIV antibody positive were as HIV/AIDS combined with TB group, another 319 patients with HIV antibody negative were as simple TB group. All the patients in the two groups were treated with anti tuberculosis. The incidence of liver injury, the type of liver injury, the time of liver injury and the prognosis of the liver injury of the two groups were compared. Results The incidence of liver injury in HIV/AIDS combined with TB group was 49.23%, which was significantly higher than that in simple TB groupwith 8.46%(P 0.05). Most of liver injury types of the two groups were mixed type, accounting for the largest proportion, the two groups were no difference(P 0.05). Patients in HIV/AIDS combined with TB group had liver damage at ~4 weeks more than those in the simple TB group, however the simple TB group appeared more frequently at ~8 weeks, and there were differences between the two groups(P 0.05). The total effective rate of HIV/AIDS combined with TB group was 71.88%, which was significantly lower than that of pure TB group with 92.59%(P 0.05). Conclusion Patients with HIV/AIDS combined with TB may be more vulnerable to liver injury during antituberculous therapy. It affect the patient prognosis. More attention needs to be paid to such patients.
【CateGory Index】： R512.91;R52