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《Strait Pharmaceutical Journal》 2006-01
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HPLC Method for Assay of Breviscapine Liposome

GAO-Zhan~1,HUANG Luo-sheng~1,ZHAO Hao-ru~1(TCM School of China Pharmaceutical University,Nanjing 210038,China)  
OBJECTIVE To establish an RP-HPLC method to determine the drug substance content of Breviscapine Liposomes.METHODS Using methanol-tetrahydrofuran-0.1% phosphoric acid(14∶14∶72) as mobile phase,the separation was performed on a DIKMA Diamonsil(TM) C_(18)(5μm 4.6×250nm) column with a flow rate of 1.0mL·min~(-1).The detective wavelength was 335nm and the column temperature was 40℃.RESULTS Peaks for scutellarin,excipients or solvents were separated well in the chromatographic file with the RP-HPLC method.Regression analysis of the data of scutellarin concentration against its peak area showed good straight line over the range:5~100 μg·mL~(-1)(r=0.9999).And the average recovery was 102.1%.CONCLUSION The method was simple,specific and accurate,and can effectively control quality of Dangguisini granules.
【CateGory Index】: R286.0
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