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《Strait Pharmaceutical Journal》 2006-01
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Pharmacokinetics of Domestic Cilostazol Tablets in Chinese Healthy Volunteers

YANG Yan-ping~1,WEN Yu-guan~2(1.Guangzhou Liwang Zhongyi Hospital,Guangdong Guangzhou 510140 China;The Department of Clinical Pharmaology,Guangzhou Brain Hospital,Guangdong Guangzhou 510370,China)  
OBJECTIVE To study the pharmacokinetics of cilostazol tablets in humman.METHODS 12male healthy sub jects received a single oral dose of 100mg cilostazol tablets.The plasma concentrations of cilostazol were determined by an improved HPLC method.Data of plasma level-time were disposed with 3P97 software.RESULTS The main pharmacokinetics parameters of cilostazol were as follow:C_(max) was(937.10±238.10)μg·L~(-1),T_(max)was(3.4±0.8)h,T_(1/2)was(20.4±10.5) h,AUC_(0-72)(12194±4024)μg/(h· L),AUC_(0-∞)was(12689±4325) μg/(h·L).CONCLUSION The pharmacokinetics of cilostazol tablets in human body accorded with wto-compartment open model.The study will offer the parameters of the pharmacokinetics for the clinical application of cilostazol.
【CateGory Index】: R96
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【Co-references】
Chinese Journal Full-text Database 3 Hits
1 LIU Rong,YAN Feng,WANG YU-jiang,DENG Xi-jun,SHI Ying-chang (The PLA 309th Hospital,Beijing 100091,China);Study on penetration diffusion of Diclofenac Gel preparations with different concentrations of Azone[J];West China Journal of Pharmaceutical Sciences;2004-04
2 ZHU Hai-tao,CHEN Ji-yan,LAN Hong,ZHANG Xiu-hua,LI Ming-hui(Affiliated Taihe Hospital,Yunyang Medical College,Shiyan 442000,China);Production and Determination of the Content in Baoshen Capsules[J];LiShiZhen Medicine and Materia Medica Research;2006-04
3 LU Lei1,ZHANG Huai-qin2,CHEN Guo-rong2,WU Jian-bo2,CHEN Zhi-li1,ZHOU Xue-ying1,JIANG Chang-hao1(1.Yiwu City Center Hospital,Zhejiang Province,Yiwu 322000,China;2.The First Hospital Affiliated with the Wenzhou Medical College,Wenzhou 325000,China);Effects of Berberine on the Expression of GPVI on Platelets of Diabetes Rats[J];Herald of Medicine;2007-11
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 Miao Fusheng(Academic Journal Center,Ningxia University,Yinchuan 750021,China);The Universal Solution to Process Illustrations for Sci-tech Journals with Cooperative Edit[J];Journal of Ningxia University(Natural Science Edition);2009-02
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