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《Strait Pharmaceutical Journal》 2006-03
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Determination of Olanzapine in Plasma by HPLC with UV Detection

LIU Wei-zhong,HUANG Wei-qiao,FU-yan(Clinical Pharmacology,Guangzhou Psychiatry Hospital,Guangzhou510370,China)  
OBJECTIVE To establish a method for determining the plasma concentration of olanzapine by HPLC.METHODS Olanzapine was extracted with diethyl ether.The residues were analyzed with a reverse phase HPLC system Diamonsil C_(18) column(150mm×4.6mm,5μm) with the mobile phase consisted of 0.03mol·L~(-1)NH4AC-Methanol(35∶65).The detection wavelength was at 275nm.RESULTS The average recoveries of olanzapine were 102.92%,97.11% and 98.20%,respectively.The within-day and between-day precision of variation was less than 6%.The calibration curves of olanzapine had good linearity,r=0.9996(n=9),over the range of 5.0~320.0μg·L~(-1).CONCLUSION The method provides a sensitive,accurate precise and reliable analytical procedure for clinical monitoring of olanzapine in plasma and its pharmacokinetics studies.
【CateGory Index】: R96
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