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《Strait Pharmaceutical Journal》 2006-03
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Determination of the Contents of tinidazole in Blood Plasma by HPLC

QIU Ping-ying,WEN Yu-guan(Guangzhou Brain Hospital,Guangzhou 510370,China)  
OBJECTIVE To develop a HPLC method for quantitative determination of tinidazole in blood plasma.METHODS Tinidazole was extracted with ethyl acetate and dichloromethane(4∶1).The residues were analyzed with a reverse phase HPLC system(Diamonsil~(TM)C_(18)column,250mm×4.6mm,5μm);mobile phase was methanol-0.03 mol·L~(-1)NH_4AC(25∶75,V/V);the detection wavelength was at 320 nm.RESULTS The average recoveries for tinidazole were 111.01%,99.00% and 100.74%,respectively.The within-day(n=5) and between-day(n=3) relative standard deviations was 5.87% and 7.82%,respectively.The calibration curve for tinidazole was linear in the range of 0.25 to 75 mg·L~(-1),(r=0.999 9).The limits of quantitation for tinidazole was 0.05 μg·L~(-1).CONCLUSION The method provides a sensitive,accurate,precise and reliable analytical procedure for clinical monitoring of tinidazole blood plasma and its phamacokinetic studies.
【CateGory Index】: R96
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1 FENG Yu-fei, YOU Yang, YIN Qi ,LIU Lei ,SHI Ai-xin ,LI Ke-xin ,SUN Chun-hua (Clinical Pharmacology Base of Beijing Hospital, Beijing 100730, China ; School of Pharmaceutical Sciences , Beijing University, Beijing 100083 , China );The pharmacokinetics study of tinidazole colon-specific enteric-coated tablets in healthy volunteers[J];Chinese New Drugs Journal;2004-04
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1 WEN Yu-guan~(1),LIAO Ri-fang~(2),CHEN Jian-yu~(1),MA Cui~(1),CHEN Mei-wan(1.Department of Clinical Pharmacology,Guangzhou Brain Hospital,Guangdong Guangzhou 510370,China;2.Sun Yat-Sen Hospital,Sun Yat-Sen University,Guangdong Guangzhou 510120,China;3.Jinan University,Guangdong Guangzhou 510730,China);The pharmacokinetics study of tinidazole colon-specific enteric-coated tablets in Chinese healthy volunteers[J];Chinese Journal of Hospital Pharmacy;2006-11
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