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《Strait Pharmaceutical Journal》 2018-08
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Reaserch Advances of Small Molecular Activators of Glucokinase

ZHU Lin-qiang;ZHU Xiong;China Pharmaceutical University;  
Glucokinase is one of four members of the hexokinase. In the liver,it promotes the synthesis of hepatic glycogen and reduces hepatic glucose output. In pancreatic β-cell,it regulates the secretion of insulin. It' s lowering blood glucose in liver and pancreas play an important role in glucosehomeostasis. Glucokinase is a new target for the therapy of type 2 diabetes. Small molecular activators of glucokinase can increase the affinity of glucokinase with glucose and the maximal enzymatic reaction rate of glucokinase by activated glucokinase. As so far,there are more than20 candidate drugs into clinical trials,the fastest has entered Phase Ⅲ clinical. GKA are divided into complete activators and liver selective activators.
【CateGory Index】: R977.15
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