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《Strait Pharmaceutical Journal》 2018-08
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Preparation and Evaluation of Okra Flavonoids Oral Ulcer Film

ZHANG Chang-ze;CHEN Juan;Dept.of Pharmacy,Zhongshan Hospital Affiliated to Xiamen University;  
OBJECTIVE To prepare flavonoids oral ulcer film extracted from okra,and evaluate the quality of the film. METHODS The films were prepared using tape-casting technology,and the preparation process were optimized by orthogonal experiment with the concentration of chitosan( A),glycerol( B) and gelatin( C) as factors. The adhesion,dissolution time and dissolution rate in vitro of the film were used as evaluation indexes. RESULTS The optimized formula was as follows: A = 2. 9%,B = 13. 0%,C = 1. 75%. The films were well shaped andmeet the requirements,released well in artificial saliva. CONCLUSION The preparation process of flavonoids oral ulcer film extracted from okra is reasonable and the quality meets the requirements of pharmacopoeia.
【CateGory Index】: R283
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