Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Strait Pharmaceutical Journal》 2018-08
Add to Favorite Get Latest Update

Resveratrol Inhibits Hypoxia Induced Invasion of HepG2 Cells and Decreased the Expression of CXCR4

LI Jian-kun;WANG Shun-xiang;XU Zhuo;YANG Bao-ming;Fourth Affiliated Hospital of Hebei Medical University;  
OBJECTIVE To investigate the effect of different concentrations of Resveratrol on invasion of HepG2 cells and to explore its mechanism. METHODS The effects of Resveratrol on the invasion and metastasis of HepG2 cells under hypoxia conditions were detected by transwell test; Western blot was used to detect CXCR4 expression; the effects of AMD3100 on the invasion and metastasis of HepG2 cells was observed by transwell test. RESULTS Compared with the control group,Resveratrol could inhibit the invasion and metastasis of HepG2 cells in a concentration dependent manner,and Western blot showed that Resveratrol could reduce CXCR4 protein expression; AMD3100 incubation Significantly reduced the invasion and metastasis of HepG2 cells. CONCLUSION Resveratrol can inhibit the invasion and metastasis of HepG2 cells under hypoxia conditions,the mechanism may be involved the decrease of CXCR4 protein expression by Resveratrol.
【Fund】: 河北省中医药管理局科研计划项目 项目名称“基于CXCR4研究白藜芦醇对肝癌细胞侵袭转移的影响”(2014144);; 河北省高等学校科学技术研究项目 项目名称“沙滩黄芩提取物在c57小鼠左侧颈总动脉结扎后新生内膜增生中的作用及其机制”(QN2017104)
【CateGory Index】: R285
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved