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《Strait Pharmaceutical Journal》 2018-08
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Simultaneous Determination of Six Active Components in Tongqiao Biyan Tablets by UPLC

ZHANG Ying-shuai;LIN Yong-gen;LIU Ni-fu;GONG Yu;LI Fu-Jun;Zhuzhou QianJin Pharmaceutical Company Limited;  
OBJECTIVE To establish an UPLC method for determination of prim-o-glucosylcimifugin,5-Omethylvisamminol,calycosin-7-O-β-D-glucoside,magnolin,imperatorin,isoimperatorin in Tongqiao Biyan Tablets. METHODS Waters BEH C_(18) column( 50 mm × 2. 1 mm,1. 7μm) was eluted with the mobile phase of acetonitrile-0. 2‰ acetic acid water in a gradient mode. The flow rate was 0. 5 mL·min~(-1). The detection wavelength was set at 254 nm. RESULTS prim-o-glucosylcimifugin,5-O-methylvisamminol,calycosin-7-O-β-D-glucoside,magnolin,imperatorin,isoimperatorin had a good linearity within the ranges of 0. 025 ~ 0. 8μg,0. 04 ~ 1. 28μg,0. 025 ~ 0. 8μg,0. 03 ~ 0. 96μg,0. 03 ~ 0. 96μg,0. 10 ~ 3. 20μg,with the recoveries between 97. 5% and 99. 5%. CONCLUSION This method is simple,accurate,highly reproducible and can act as an important index to control the quality of the preparation.
【CateGory Index】: R286.0;O657.72
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