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《Strait Pharmaceutical Journal》 2018-08
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Comparison Two Methods of Detecting Fine Particle Dose in Salbutamol Sulfate Inhalation Aerosol

WANG Xin;LIU Hong-da;XUE Yan;DI Wei-qing;WANG Hong-ying;Penglai Nuokang Pharmaceutical Co.Ltd;Liaoning Grand Nuokang Biopharmaceutical Co.LTD;  
OBJECTIVE Fine particle dose of salbutamol sulfate inhalation aerosol was determined by twinstage impactor( TSI) and multistage( 8) impactor( Andersen cascade impactor,ACI) separately and comparative analysis of the results. METHODS Analyzed fine particle dose by TSI and ACI which used Salbutamol inhalation aerosol as a model. RESULTS TSI analyzed fine particle dose which was less than 6. 4μm rapidly couldn't get the aerodynamic particle size distribution. But ACI could analyze both; Both TSI and ACI should to control the airflow in order to ensure aerodynamic particle size distribution accurately detected. CONCLUSION Compared with TSI,ACI is more comprehensive for evaluating salbutamol sulfate inhalation aerosol.
【CateGory Index】: R927.2
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