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《Strait Pharmaceutical Journal》 2018-08
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Feasibility Analysis of the Treatment of Reflux Esophagitis with ZhiShuKuanZhong Capsule

LI Xue-hua;HUANG Qing-hui;LI Peng;Dongguan East City Hospital pharmacy department clinical pharmacy room;  
OBJECTIVE To explore the clinical effect of ZhiShuKuanZhong wide capsule in the treatment of reflux esophagitis with esomeprazole and Mosapride. METHODS The clinical data of 450 patients with reflux esophagitis in our hospital from January 2016 to December 2017 were retrospectively analyzed. According to the methods of drug use,the patients were divided into 2 groups. 225 cases in the control group were treated with esomeprazole and Mosapride,and 225 cases in the study group were treated with ZhiShuKuanZhong capsule. The clinical efficacy,symptom score and incidence of adverse reactions were compared between the two groups. RESULTS The total effective rate of the study group( 95. 56%) was significantly higher than that of the control group( 83. 11%)( P 0. 05). There was no significant difference in the main symptom scores of the two groups before treatment( P 0. 05). The scores of the main symptoms in the two groups were significantly lower after treatment,and the study group was lower than the control group( P 0. 05). The incidence of adverse reactions( 6. 66%) in the study group was not significantly different from that in the control group( 6. 2%)( P 0. 05). CONCLUSION The treatment of esomeprazole and mosapride with ZhiShuKuanZhong on the treatment of reflux esophagitis can significantly improve the clinical symptoms and improve the clinical efficacy.
【Fund】: 广东省东莞市社会科技发展(一般)项目(编号:201650715001484)
【CateGory Index】: R259
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