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《Journal of Hebei University(Natural Science Edition)》 2006-01
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Study on F01-195A,an Aldose Reductase Inhibitor from Metabolites of Microorganisms

REN Xiao,DONG Yue-sheng,ZHANG Hua,LU Xin-hua,ZHENG Zhi-hui,LIU Mei,HE Jian-gong(National Microbial Medicine Engineering & Research Center,New Drug Research and Development Co.,Ltd.of North China Pharmaceutical Corporation,Shijiazhuang 050015,China)  
A high throughput screening method established by us was applied for screening aldose reductase inhibitors from thousands of strains of actinomycetes and fungi,as a result,a strain,F01-195 with the positive activity was picked out.The culture broth of the positive strain was purified by solvent extraction,silica column chromatography and ODS HPLC to get an active compound named F01195A.The compound showed strong specific inhibitor activity against aldose reductase with IC-(50) of 57.2 μmol/L.By the physicochemical data of UV,MS,NMR and so on,the structure of F01-195A was determined as the same as Flavomannin,which was reported as a lead compound to promising drugs against the human malaria parasite.
【Fund】: 国家科技部 创新药物筛选技术平台研究项目(2002AA2AZ343D)
【CateGory Index】: TQ464
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