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《Journal of Hebei University(Natural Science Edition)》 2006-01
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Study on F01-2076A,a Acetylcholinesterase Inhibitor from Fungus

LIN Jie~(1,2),ZHANG Peng~2,ZHENG Zhi-hui~1,DONG Yue-sheng~1,LU Xin-hua~1(1.National Microbial Medicine Engineering & Research Center,New Drug Research and Development Co.,Ltd.of North China Pharmaceutical Corporation,Shijiazhuang 050015,China;2.College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China)  
A high throughput screening method was established for screening AchE inhibitor from fungus.As a result,an active strain,F01-2076 was isolated.The culture broth of it was processed by solvent extraction,SiO-2 column chromatography and ODS HPLC purification,then an active compound named F01-2076A was got.The compound showed inhibitory activity against AchE of IC-(50) 23.4 μmol/L.By means of physical-chemical properties,()~(13)C-NMR and()~1H-NMR analysis,the structure of this compound was identical with the Altenusin.It was reported as myosin light chain kinase inhibitor and sphingomyelinase inhibitor.The compound is discovered as a AchE inhibitor for the first time.
【Fund】: 国家科技部创新药物筛选技术平台研究基金项目(2002AA2AZ343D)
【CateGory Index】: R971
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