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《Journal of Hebei University(Natural Science Edition)》 2006-01
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Isolation,Distribution and Physiological Activity of Ascomycete

LIU Mei~(1,2),ZHANG Peng~1,CUI Xiao-lan~2,DING Yan-bo~2,ZHENG Zhi-hui~2,DONG Yue-sheng~2,ZHANG Hua~2(1.College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China;2.National Microbial Medicine Engineering & Research Center,New Drug Research and Development Co.,Ltd of North China Pharmaceutical Corporation,National Microbial Medicine Engineering & Research Center,Shijiazhuang 050015,China)  
The number of Ascomycote isolated from soil samples by the selective method was 2.8 times as that by the conventional method.The distribution of Ascomycote in Hebei,Guangxi and Yunnan provinces was investigated.The results showed that Ascomycote was much abundant in soil of Yunnan province.The metabolites of isolated fungi were then screened by drug screening models and the hit rate of metabolites produced by Ascomycote was 2.3 times as that of other fungi in the Caspase-3 inhibitor screening.
【Fund】: 国家科技部创新药物筛选技术平台研究资助项目(2002AA2AZ343D)
【CateGory Index】: Q939.9
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