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《Journal of Hebei University(Natural Science Edition)》 2007-04
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Synthesis of Molecularly Imprinted Polymeric Microspheres with Ciprofloxacin as Template and the Study of Their Binding Characteristics

LIU Zhan-li1,ZHU Yin-sheng2,GAO Jun-gang1,LIU Peng-yan1 (1.College of Chemistry and Environmental Science,Baoding 071002,China;2.Xingtai Ailite Chemical Industry Co.Ld.,Xingtai 054001,China)  
The molecularly imprinting microspheres(MIPMs) were prepared with suspension polymerization using ciprofloxacin as template and methacrylic acid as functional monomer.Polymers were characterized with IR and TGA.The batch way was used to investigate the selectively binding ability of the MIPMs for ciprofloxacin and analogue.Saturated amount of adsorption toward ciprofloxacin was finished in 4 houres.Imprinting factor and maximum surface adsorption quantity of MIPMs2 is 1.58 and 183.18 μmol/g respectively with best imprinting effect.Scatchard analysis showed that two classes of binding sites were formed in the molecularly imprinting polymer under the studied condition.The results showed that the imprinted polymer exhibited a high selective binding for ciprofloxacin and reusable property could be applied for analysis and separation of ciprofloxacin.
【Key Words】： molecularly imprinting template suspension polymerization ciprofloxacin
【Fund】： 河北省自然科学基金资助项目(B2005000108)
【CateGory Index】： TQ463
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