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《Journal of Hebei University(Natural Science Edition)》 2008-05
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Cellular Uptake of Cisplatin Metabolite [Pt(L-Met-S,N)_2]

WEI Hai-ying1,MA Jiu-fen1,SHAO Ying2,CAI Yong-xuan1,CHEN Yan-hong1(1.College of Chemistry and Environmental Science,Hebei University,Baoding 071002,China;2.Department of Chemistry,Shaoxing University,Shaoxing 312000,China)  
The uptake of complex [Pt(L-Met-S,N)2] by Jurkat tumor cells and normal sheep red blood cells was carried out in comparison to that of cisplatin.The intracellular Pt content was determined by inductively coupled plasma mass spectrometer(ICP-MS).The experimental results showed that the two cellular uptake curves for complex [Pt(L-Met-S,N)2] are consistent.Howerer,the cellular uptake ability of complex [Pt(L-Met-S,N)2] is much lower than that of cisplatin.The data confirmed that the biological inactivity of complex [Pt(L-Met-S,N)2] in vivo may be relevant to its lower cellular uptake.
【Fund】: 河北省教育厅自然科学基金资助项目(2007107);; 河北大学自然科学博士基金资助项目(2005056)
【CateGory Index】: R96
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1 MU Yongping,WU Gang,QIAO Xiuwen,ZHOU Lishe,HE Yanling(Department of Biochemistry and Molecular Biology,Research Center of Biology and Medicine,Research Institute of Trace Element in Organism,Baotou Medical College,Baotou 014010,China);The Transport and Absorption of Chiral Metal Domplexes d,l-[Ni(phen)_3]~(2+) across the Model of Caco-2 Cell Monolayers[J];Journal of Baotou Medical College;2006-04
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