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《Journal of Hefei University of Technology(Natural Science)》 2006-06
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Synthesis of 2,6-dichloropurine

LI Ye-qing,LU Ming,L Chun-xu(School of Chemical Engineering,Nanjing University of Science and Technology,Nanjing 210094,China)  
2,6-Dichloropurine was prepared from methyl cyanacetate by the reactions of cyclization,nitrosylation,reduction,closed ring action,thionation and chloration.There are many processes simply dealt with to the next reaction,so the process of the whole reaction was rather simple.The factors that effect the reaction are discussed,including the key raw materials,the size of the particles,the temperature and the solvent of reaction.The total yield was 30%~32%.The target compound was analyzed by IR and UV to make sure it is 2,6-dichloropurine and the assay of the product was measured by HPLC.The technology was suitable for industrial production.
【CateGory Index】: TQ25
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【References】
Chinese Journal Full-text Database 1 Hits
1 MA Jian-bing,ZHENG Xue-ming,SHANG Hui-jian,ZHANG Lei(College of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang Hebei 050018,China);Research and application of cyanoacetic acid[J];Hebei Journal of Industrial Science and Technology;2009-05
【Co-references】
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1 LIU Fu-Sheng, YU Shi-Tao, GE Xiao-Ping, YANG Jin-Zong (College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China; State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China);Studies on Synthesis of 2-Substituted-purine Derivatives[J];Chemical Research In Chinese Universities;2003-09
2 YUAN De-Kai,LI Zheng-Ming~*,ZHAO Wei-Guang,FAN Zhi-Jin,WANG Su-Hua(The Institute of Elemento-Organic Chemistry,State Key Laboratry of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China);Synthesis and Biological Activity of a Series of Poly-substituted Purines[J];Chemical Journal of Chinese Universities;2006-02
3 ZHAN Pei ying, FENG Ya qing,ZHANG Wei hong (School of Chemical Engineering, Tianjin University, Tianjin 300072, China);Synthesis and Application of 2-Aamino-6-chloropurine[J];Chemical Industry and Engineering;2001-02
4 Luo Xiaoyan (Department of Pharmaceutics,Wuhan Institute of Chemical Technology,Wuhan 430074);The synthesis of antiviral drug Acyclovir[J];Chemical Reagents;2001-03
5 YAO Er-dong,WU La-mei,XU Xue-song,ZHANG Lei,QIU Guo-fu~*,HU Xian-ming (College of Pharmacy,Wuhan University,Wuhan 430072,China);One-pot synthesis of ethyl 3,3-diethoxyacrylate[J];Chemical Reagents;2006-09
6 LU Hong-fei,LU Ming,Lü Chun-xu(Chemical Engineering School,Nanjing University of Science and Technology,Jiangsu Nanjing 210094,China);Study on the Synthesis of N~2·9-Diacetylguanine[J];Chemical World;2006-03
7 LI Zi cheng 1,CHEN Shu hua 1,JIANG Ning 2,LU Ding 2 (1.Faculty of Chemistry,Sichuan University,Chengdu 610064,China; 2.Sichuan Industrial Institute of Antibiotics,Chengdu 610051,China);Progress of uncleosides as antiviral agents[J];Chemical Research and Application;2002-01
8 LIU Fu sheng 1,YANG Jin zong 2 (1.College of Chemical and Pharmaceutical Engineering,Qingdao Institute of Chemical Technology,Qingdao 266042, China;2.State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116012,China);Synthesis of 8-R-9-Benzyl-9H-purines[J];Fine Chemicals;2002-04
9 LIU Qi-bin~1,SHEN Yan-hong~2,QU Gui-rong~(1*),LI Yong~1 (1.College of Chemistry and Environmental Science,He′nan Normal University,Xinxiang 453002,He′nan,China;2.Department of Chemical Engineering,Anyang University,Anyang 455000,He′nan,China);Synthesis of 6-Chloro- and 6-Methoxypurinenucleoside[J];Fine Chemicals;2004-12
10 LU Hong-fei,LU Ming~,L Chun-xu,HE Ying,ZHANG Kang-kang(Chemical Engineering School,Nanjing University of Science and Technology,Nanjing 210094,Jiangsu,China);Synthesis of 2-Amino-6-halogenpurine[J];Fine Chemicals;2006-04
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 XIONG Xiao-yi,CHEN An-qun,HE Yong-mei(Chongqing Unis Chemical Co.,Ltd.,Chongqing 402161,China);Analysis of Cyanoacetic Acid Content by HPLC[J];Guangzhou Chemical Industry;2010-12
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