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Synthesis of 4-Fluoroaniline

Xu Dezhong(R&D Center of Zhejiang Fusheng Holding Group Co.Ltd.,Changshan,Zhejiang 324202)  
4-Fluoroaniline is synthesized in two steps from p-nitrochlorobenzene and active potassium fluoride.Optimum conditions are as follows:DMF is used as solvent,compound quaternary ammonium salt as catalyst,n(p-nitrochloro benzene):n(KF)=1:1.2,m(catalyst):m(p-nitrochloro benzene)=4%,m(DMF):m(p-nitrochloro benzene)=1:1,and reacted under 155~160 ℃ for 18 h;reduction reaction is carried out in methanol with Raney nickel,which is used as catalyst;the raw product is added an antioxidant,and distilled simply under reduced pressure to obtain 4-fluoroaniline with excellence quality,purity is over 99.5%,total yield is 89.3%.2 moths later it is stored uncorked in room,no color change is obvioused,which shows this process has some value in industry.
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