Coordinating Reaction of 5-Fluorouracil-Porphyrin with Copper (Ⅱ) and Its Catalysis
Hu Zhenzhu, Wang Weidong (Chemistry and Environmental Engineering College, Hubei Normal University, Huangshi, Hubei 435002)
Apparent rate constant and apparent activation energy are determined in the coordinate reaction of 5-fluorouracil porphyrin with Cu(Ⅱ) by spectrometry method. Equilibrium constant and related thermodynamic parameters in the formation of metal porphyrin are determined with a mobile equilibrium method, catalysis of Cd (Ⅱ) on the reaction and effect of different solvents on the reaction ratio are discussed. Results show that activation energy in the coordinate reaction of H2P and Cu(Ⅱ) Ea=64.13 kJ/mol, reactive △rHm= -20.552 kJ/mol, △rSm = 6.787 J/mol; Cd2+ has catalysis on the reaction, when the Cd2+ concentration is not big, rate constant k has the linear relationship with Cd2+ concentration; the smaller the dielectric constant is, the bigger the reaction rate is.