The Progresses of Mechanically Activated Metal-Catalyzed Coupling Reaction
Pan Heng;Xu Xin;Shi Leizhou;Ji Ye;Li Jianjun;Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education,Zhejiang University of Technology;
The concept, development process and reaction equipment of mechanochemistry were briefly introduced. On the base of the introduction, this review presented its application in Suzuki, Heck, Sonogashira, CDC and Glaser reaction. And the characteristics of the reactions had been studied. The mechanochemistry did not require any toxic organic solvents. Also, short reaction time, high yields and simple isolation of the production all make this method fully embodied the concept and development direction of green chemistry. As a new way to promote solvent-free reactions, mechanochemistry becomes an effective tool for metal-catalyzed coupling reaction. Moreover, there are many disadvantages. To realize industrial production, we also need to further study of reaction mechanism and influence factors.