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《Acta Scientiae Circumstantiae》 1986-01
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A STUDY ON MUTAGENICITY OF “RUSTPROOF FLUID” MADE IN CHINA AND ITS VARIOUS INGREDIENTS

Huang Weiqun, Wang Hengwen (Shanghai Institute of Cell Biology, Academia Sinica)  
Rustproof fluid" comprised of sodium nitrite, polyethylene glycol and triethanolamine was found to be mutagenic both directly and after microsomal activation to Salmonella typhimurium TA100 strain in Ames test with dose-response effect. Results of Ames test with its main ingredients demonstrated that both impurities in crude sodium nitrite and some substances formed during its storage were directly mutagenic to Salmonella typhimurium. Further work showed that analytical reagent grade sodium nitrite itself was negative in direct Ames test. But "rustproof fluid" comprised of analytical reagent grade sodium nitrite, polyethylene glycol and triethanolamine was positive in both direct and indirect Ames tests. It implied that sodium nitrite might react with triethanolamine to form some new direct-or indirect- acting mutagens. It is suggested that N-nitroso compounds were synthesized in vivo or in vitro from sodium nitrite and triethanolamine in the formula of "rustproof fluid".
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【References】
Chinese Journal Full-text Database 1 Hits
1 Wang Da, Wang Hengwen (Shanghai Institute of Cell Biology, Academia Sinica);A STUDY ON THE CARCINOGENICITY OF “RUSTPROOF FLUID” MADE IN CHINA[J];Acta Scientiae Circumstantiae;1986-02
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 Wang Da, Wang Hengwen (Shanghai Institute of Cell Biology, Academia Sinica);EFFECT OF LONG-TERM ASCORBIC ACID INGESTION ON THE CARCINOGENICITY OF "RUSTPROOF" FLUID IN WISTAR RATS[J];Acta Scientiae Circumstantiae;1986-03
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