Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Natural Science of Heilongjiang University》 2009-03
Add to Favorite Get Latest Update

Optimization of combined extraction of glycyrrhizic acid and flavonoids by response surface methodology

LI Chun-ying,LI Xiao-juan,YANG Lei,ZHAO Chun-jian,LI Jia-hui,ZU Yuan-gang(Key Laboratory of Forest Plant Ecology,Ministry of Education,Northeast Forestry University,Harbin 150040,China)  
Response surface analysis methodology(RSM) was used for optimizing the extraction process of glycyrrhizic acid and flavonoids from glycyrrhiza.Based on single-factor experiments,three independent variables,reflux solvent,time and ratio of liquid to solid were selected as affecting factors during extraction.An expevimental design of 4 factors and 5 levels was arranged according to central composite model.Response surface analysis was carried out based on the yields of glycyrrhizic acid and flavonoids as response values.The results showed that the optimal conditions for combined extraction were 68% of ethanol,1.1 % sodium hydroxide,reflux time of 2.5 h and liquid solid the ratio of was 10.1 ∶1(mL ∶g).Under the condition,the yield of glycyrrhizic acid is 5.68% and the yield of flavonoids is 6.73%.
【Fund】: 国家科技支撑计划项目(2006BAD18B04)
【CateGory Index】: TQ461
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 8 Hits
1 Cao Dongmei,Hu Yaohui(College of Food Science and Engineering,Jilin Agricultural University,Changchun 130118,P.R.China);Fermentation Optimization for the Production of β-Cyclodextrin Glycosyltransferase by Thermophilic Strain HY15 Using Response Surface Methodology[J];Journal of Northeast Forestry University;2012-01
2 JIANG Fu-jia,WANG Yu-ping,ZHOU Chang,ZHANG Xiao-jian,ZHOU Jie,MENG Qing-fan (College of Life Science,Jilin University,Changchun 130012,China);Extraction Conditions of Grains Protein[J];Journal of Jilin University(Science Edition);2010-01
3 WANG Xiu-li1,2,REN Xiao-dong2,CHEN Ping-ping3,HAN Wen-yu1,TENG Li-rong2 (1. College of Animal Science and Veterinary Medicine,Jilin University,Changchun 130062,China; 2. College of Life Science,Jilin University,Changchun 130012,China; 3. College of Medicine,Yanbian University,Yanji 133002,Jilin Province,China);Statistical Optimization of Fermentation Medium for Nisin Production[J];Journal of Jilin University(Science Edition);2010-02
4 XUN Er-na1,ZHANG Chun-li2,XIE Xiao-na3,CHEN Shu-ping2,ZHOU Xin-hui1, WANG Jia-xin1,WANG Lei1,WANG Zhi1(1.Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education,Jilin University, Changchun 130012,China;2.College of Physical Education,Jilin University,Changchun 130012,China; 3.Department of Endocrinology,First Hospital of Jilin University,Changchun 130021,China);Ultrasonic-Assisted Extraction of Polyphenol from Needles of Pinus prokoraiensis[J];Journal of Jilin University(Science Edition);2012-01
5 XIE Li-yuan,TAN Wei,GUO Yong,JIA Ding-hong,PENG Wei-hong,GAN Bing-cheng(Institute of Soil and Fertilizer,Sichuan Academy of Agricultural Sciences,Chengdu 610066,China);Application of Response Surface Methodology for Optimization of Liquid Fermentation Medium for Intracellular Polysaccharide Production by Phellinus baumii[J];Food Science;2011-07
6 Wang Wei Geng Fei Hu Xiao Zhou Tao*(Department of Food Science and Nutrition,Nanjing Normal University,Nanjing 210097);Bacteriostatic Action of Liquorice Extract Against E.coli O157∶H7 in Dried Bean Curd and its Fresh Keeping Action[J];Journal of Chinese Institute of Food Science and Technology;2012-01
7 CHEN Jing1,2,WEN Qing-guo1,LIU Shao1,LI Xin-zhong1 1.Xiangya Hospital,Central South University,Changsha 410008,China 2.Department of Pharmacy,Changsha Central Hospital,Changsha 410004,China;Optimization for purifying technology of Nelumubinis Plumula extract with chitosan by comparison of orthogonal design and response surface method[J];Chinese Traditional and Herbal Drugs;2012-11
8 ZHU Bing-ya,CHENG Wei*( Pharmacy School,Liaoning Medical University,Jinzhou 121000,China);Preparation optimization of aloe-loaded chitosan nanoparticles by response surface methodology[J];Chinese Traditional Patent Medicine;2013-09
Chinese Journal Full-text Database 9 Hits
1 LING Xiu-ji~1,WAN Duan-ji~1,WU Zheng-qi~2(1 School of Chemisry and Envirnment Engin.,Hubei Univ.of Technology,Wuhan 430068,China;2 School of of Biological Engin.,Hubei Univ.of Technology,Wuhan 430068,China);Research on Extraction Technology of Glycyrrhizic Acid[J];Journal of Hubei University of Technology;2006-02
2 LI Xiu-liang, XIE liang, WANG Zhang (College of Life Science, Heilongjiang University, Harbin 150080, China; College of Food Science, Jiangnan University, Wuxi 214036, China);Optimum process conditions of extracting sesame protein and oil by aqueous extraction[J];Journal of Natural Science of Heilongjiang University;2001-04
3 ZHAO Hui, WU Guo-feng, ZHANG Ke-chang(Institute of Life Sciences, Heilongjiang University, Harbin 150080, China;Institute of Biology Engineering, Jiangnan University, Wuxi 214036, China);Technology study of normal pressure acid hydrolysis on corncob hemicellulose[J];Journal of Natural Science of Heilongjiang University;2003-01
4 Xiao Weihua1,2,Han Lujia1,2,Yang Zengling1,2,Liu Xian1,2 (1.College of Engineering,China Agricultural University,Beijing 100083,China;2.Key Laboratory of Modern Precision Agriculture System Integration,Ministry of Education,Beijing 100083,China);Optimization of alcohol extraction techniques of flavonoids from Radix Astragali using response surface methodology[J];Journal of China Agricultural University;2007-05
5 WANG Zhen-Zhong,WU Wen-Jie (College of Marine Science and Engineering,Tianjin University of Science & Technology,Tianjin 300222,China);The Optimal Extracting Conditions for Chrysanthemum Indicum L.by Response Surface Design(RSD)[J];Lishizhen Medicine and Materia Medica Research;2007-03
6 ZHAO Wei-xing1,SUN Zhi-qiang1,GAO Yu-hong2,ZHANG Nan1,REN Zi-jun1 (1 College of Forestry and Horticulture,Henan Agricultural University,Zhengzhou,Henan 450002,China;2 Department of Biology,Zhengzhou Vocational and Technological College,Zhengzhou,Henan 450121,China);Optimization of extraction technique of total alkaloid from Radix Stemona via Response Surface Methodology[J];Journal of Northwest A & F University(Natural Science Edition);2008-07
7 WU Wei-ping~1 SUN Wen-ji~(1*) YAN Hong-tao~1 CAO Ai-lan~2 (1.Biology and Medicine Key Laboratory of Northwest University,Xi'an 710069; 2.Institute of Chinese Traditional Medicine of Shaanxi,Xianyang 712000);Determination of Total Flavone in Licorice by Spectrophotometry[J];Chinese Journal of Pharmaceutical Analysis;2005-04
8 Zhang Xunjie1,3 Wang Jie2 Xie Baogui2 Cai Zhixin2 Chen Shaojun1 (1Fujian Agriculture and Forestry University,College of Food Sciences,Fuzhou,Fujian 350002 2Fujian Agriculture and Forestry University,Research Center of Fungi,Fuzhou,Fujian 350002 3Fujian Hwa Nan Women’s College,Fuzhou 350007);Optimization of the Extraction Technology of Antrodia Camphorata Polysaccharide Using Response Surface Method[J];Journal of Chinese Institute of Food Science and Technology;2008-01
9 YAN Xiang-yang,LlU Jian-ping,XIA Ji-hong,MA Xue-ping(College of Chemistry and Chemical Engineer,Henan University of Technogy,Zhengzhou 450052,China);STUDY ON THE EXTRACTION OF LICORICE FLAVONOID AND INHIBITING NITROSAMINE REACTION[J];Journal of Henan University of Technology(Natural Science Edition);2007-02
Chinese Journal Full-text Database 10 Hits
1 Tang Ning(The Department of Life Science,Nanjing Xiaozhuang College,Nanjing,Jiangsu,211171);Studies on Radiation Breeding of Atractylodes Macrocephala Koidz[J];Anhui Agricultural Science Bulletin;2007-23
2 Tang Ning(The Department of Life Science,Nanjing Xiaozhuang College,Nanjing,Jiangsu,211171);Studies on Anti-oxygen Activities of Radiation Lines of Atractylodes Macrocephala Koidz.[J];Anhui Agricultural Science Bulletin;2007-24
3 LI Hai-bo et al(Yingdong College of Bioengineering,Shaoguan University,Shaoguan,Guangdong 512005);Study on Extraction Technology of polysaccharide in Asystasia gangetica(L.)T.Anders[J];Journal of Anhui Agricultural Sciences;2007-32
4 HONG Wei-ming et al (Department of Animal Pharmaceutics,Jiangsu Animal Husbandry & Veterinary College,Taizhou,Jiangsu 225300);Preliminary Study on the Effects of Zizhuliqing on Animal Cellular Immune Function[J];Journal of Anhui Agricultural Sciences;2009-01
5 GAO Qian-qian et al(Shandong University(Weihai),Weihai,Shandong 264209);Preliminary Investigation on the Lactic Plants and its Medical Value in Kunyu Mountain[J];Journal of Anhui Agricultural Sciences;2009-08
6 WANG Yong et al(School of Life Sciences and Technology,North University for Ethnics,Yinchuan,Ningxia 750021);Comparison and Evaluation of Methods for Licorice Flavonoids Content Determination[J];Journal of Anhui Agricultural Sciences;2009-28
7 HU Yong-jin et al (College of Food Science and Technology,Yunnan Agricultural University,Kunming,Yunnan 650201);Study on Antibacterial Activity of Arnebia euchroma(Royle) Johnst and Isatis indigotica Fort Extracts in vitro[J];Journal of Anhui Agricultural Sciences;2010-09
8 FANG Yun,WU Xin-an,ZHAO Gang,WANG Tian-ya(The 105 Hospital of PLA,Hefei,Anhui Province 230031);Determination of astragaloside Ⅳ in caihuangweining by TLC[J];Anhui Medical and Pharmaceutical Journal;2006-06
9 WU Xin-an,ZHAO Gang,FANG Yun,WANG Tian-ya(The 105 Hospital of PLA,Hefei Anhui 230031);Determination of naringin in tongling tablet by HPLC[J];Anhui Medical and Pharmaceutical Journal;2006-08
10 HUANG Li-dan(Anhui Provincial Institute for Food and Drug Control,Hefei 230051);Determination of paeonol in radix etrhizoma cynanchi paniculati[J];Anhui Medical and Pharmaceutical Journal;2008-07
China Proceedings of conference Full-text Database 10 Hits
1 HE Ge-fei,Yi Ai-chun,Zhang shun-zhi(First hospitol of changsha, changsha,410005);Determination of Imperatorin in Qinxuan Pills by HPLC[A];[C];2009
2 GUO Li-li,WANG Jie Guang , anmen Hospital China Academy of Chinese Medical Sciences. Beijing 10053,China;Effects of Ingredient study in traditional Chinese medicine research[A];[C];2009
3 HE Ge-fei,Yi Ai-chun,Zhang shun-zhi(First hospitol of changsha,changsha,410005);Determination of Imperatorin in Qinxuan Pills by HPLC[A];[C];2010
4 GUO Li-li,WANG Jie Guang,anmen Hospital China Academy of Chinese Medical Sciences. Beijing 10053,China;Effects of Ingredient study in traditional Chinese medicine research[A];[C];2010
5 ZHANG Hong-xi,TIAN Zhen-guo (Coloproctological Hospital of University of TCM,Shenyang 110003,Liaoning,China);Clinical Study of Treating Slow Transit Constipation by Yangrang Runchangshu Decoction[A];[C];2007
6 ZHANG Jin (the coloproctological Hospital of Liaoning University of TCM,shenyang 110032,Liaoning,China);Study the Clinical Therapeutical Effect of Treating Chronic Functional Consipation by Yangrong Runchang Shudecoction[A];[C];2007
7 ;Effect of Super Fine Crushing Technique on Coumarins of Angelica dahurica[A];[C];2008
8 Yi Yankui,Chen Zhiliang (Southern Medical University,Guangzhou,510515);Probe the relation between the extracting component variety of Angelica and the technology[A];[C];2008
9 Lin hui etal The Coloproctological Dept.of Tian shan Hospital of TCM,shanghai 200051;Clinical effectiveness assess-ment of enema of yiqihuoxuerunchang formula for the Treatment of slow transit constipation.[A];[C];2010
10 REN Ni,SONG Yan-yan,WU Wei-ni,JING Xiu-fang,ZHANG Wei-min,XU Yong-ping* (College of Veterinary Medicine,Northwest A&F University,Yangling 712100,China);Effect of Extracts from Flos Lonicerae on Proliferation and Expression of Beta-Casein of Goat Mammary Epithelial Cell in vitro[A];[C];2012
Chinese Journal Full-text Database 10 Hits
1 LI Ya-li et al(School of Biological and Chemical Engineering,Inner Mongolia University of Science and Technology,Baotou,Inner Mongolia 014010);Study on the Process of Clarifying the Extracts of Total Herba cistanche Saponins with ZTC-II Clarifier[J];Journal of Anhui Agricultural Sciences;2009-08
2 ZHANG Su-lan (Continual Education Institute,Mianyang Normal University,Mianyang,Sichuan 621000);Research Progress on the Immunoregulation Activity of Aloe Polysaccharide[J];Journal of Anhui Agricultural Sciences;2009-32
3 ZHONG Fang-li et al(School of Pharmaceutical Engineering and Chemistry,Jilin Institute of Chemical Technology,Jilin,Jilin 132022);Ultrasonic Extraction Process of Total Flavonoids from the Aster[J];Journal of Anhui Agricultural Sciences;2010-16
4 GE Shao-xiang,PENG Dai-yin,LIU Jin-qi(Anhui Key Laboratory of Modernized Chinese Material Medicine,Anhui College of TCM,Hefei 230038);To select the optimal extraction technique for glechomae by employing the method of orthogonal trial with mixed levels and composite index[J];Anhui Medical and Pharmaceutical Journal;2007-06
5 Hui Junming(East China Institute of Technology, Nanjing);Hexanitrostilbene (HNS) and Its Application[J];Explosive Materials;1990-04
7 LI Li (Department of Resource and Environment science, Hubei institute for Nationalities Enshi, 445000);Study on the Extracting Method of Mulberry Flavonoids[J];Quarterly of Forest By-product and Speciality In China;2003-01
8 LING Qing-Zhi1,2 GAO Li-Li1 YUAN Huai-Bo2 WEI Zhao-Jun2* (1 Zhejiang Pharmaceutical College,Ningbo Zhejiang 315100,China;2 School of Biotechnology and Food Engineering,Hefei University of Technology,Hefei 230009,China);Optimization of Water-Soluble Polysaccharide Extraction From Mulberry Leaves by Means of Response Surface Analysis[J];Science of Sericulture;2009-03
9 ZHAO Xi,SU Ben-wen*,ZHENG Hong-fa,HUANG Huai-sheng,YUAN Ying-fang(Tea Research Institute,Hunan Academy of Agricultural Sciences,Changsha 410125,China);Study on Optimization of Ultrasound-assisted Extraction Technology of Total Flavonoids from Green Tea by Response Surface Methodology[J];Journal of Tea Science;2010-04
10 Wang Zhenyu,Xia Xianghui,Li Hongju(College of Food Science and Engineering,Northeast Forestry University,Harbin 150040,P.R.China);Optimization of Extraction Process of Total Flavonoids form Big-fruited Sea-buckthorn by Response Surface Method[J];Journal of Northeast Forestry University;2009-06
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 HUANG Xiu-xiang,LAI Hong-fang(Department of Chemistry and Life Sciences,Hechi University,Yizhou 546300,China);Extraction of polyphenols from Emilia sonchifolia (Linn)DC. by ultrasonic and semi-bionic[J];Guangdong Agricultural Sciences;2013-06
2 WANG Yinzhao;WU Zhengyun;YANG Jian;ZHANG Wenxue;Department of Food Engineering, Sichuan University;Sichuan Engineering Research Center of Spices Additives;College of Liquor Sciences, Jinjiang College, Sichuan University;;Research Progress in the Reclamation of Distiller's Grains[J];Liquor-Making Science & Technology;2013-09
3 JIANG Zhen-ju,XING Ya-ge*,XU Qing-lian,WANG Xi (School of Bioengineering,Xihua University,Chengdu 610039,China);Effect of tendering beans embryo on the quality of traditional characteristics leisure tofu[J];Science and Technology of Food Industry;2012-16
4 MA Tao 1,2 ,CHEN Wei-ling 1,* (1.College of Food Science and Technology,Shenyang Agricultural University,Shenyang 110866,China; 2.College of Chemistry,Chemical Engineering and Food Safety,Bohai University,Jinzhou 121013,China);Microbial sterilization effect of ozone to brown rice germination during the soaking process[J];Science and Technology of Food Industry;2013-02
5 ZHAO Yu-hong 1,ZHAI Ya-nan 1,WANG Zhen-yu 1,2,*(1.School of Forestry,Northeast Forestry University,Harbin 150040,China;2.School of Food Science and Engineering,Herbin Institute of Technology,Harbin 150090,China);Extraction of polyphenlols from Pinus Sylvestris L.and comparison of extraction method[J];Science and Technology of Food Industry;2013-04
6 LIANG Da-yong,ZHAO Chen,HUANG Fang,SONG Ai-rong(Shandong Provincial Laboratory of Applied Mycology,Qingdao Agricultural University,Qingdao 266109,China);Optimization of Extraction Process for Polysaccharides from Phellinus igniarius Fermentation Broth by Response Surface Methodology[J];Food Science;2013-04
7 MA Tao1,2,CHEN Wei-ling2,* (1. College of Chemistry,Chemical Engineering and Food Safety,Bohai University,Jinzhou 121013,China; 2. College of Food Science and Technology,Shenyang Agricultural University,Shenyang 110866,China);Influence of the process conditions on the content of γ-aminobutyric acid from germinated brown rice[J];Science and Technology of Food Industry;2013-06
8 Zhou Xiao-bing,Zheng Pu(The Key Laboratory of Industrial Biotechnology,Ministry of Education,School of Biotechnology, Jiangnan University,Wuxi 214122,China);Study on fermentative production of succinic acid from spirit-based distillers' grains[J];Food and Fermentation Industries;2013-02
9 CUI Feng-jie 1 , WANG Hong-yuan 1 , YANG Yan 2 , ZAN Xin-yi 1 , SUN Wen-jing 1 , ZHANG Zhi-cai 1 , HUANG Da-ming 1 (1.School of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013;2.National Engineering Research Center of Edible Fungi, Shanghai Academy of Agricultural Sciences, Shanghai 201403);Optimization of submerged culture conditions of Phellinus linteus W-Ⅱ by response surface methodology[J];Food Science and Technology;2013-08
10 SUN You-you CHEN Yuan-cai CHEN Hong-lei (State Key Lab of Pulp and Paper Engineering,South China University of Technology,Guangzhou,Guangdong Province,510640);Treatment of Pulp and Paper Effluent by the Immobilization of Screened Dominant Bacterial Strains[J];China Pulp & Paper;2011-08
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 JI Song-gang~1,LI Xiang~2,LOU Zi-yang~3,WANG Bin~4,CHAI Yi-feng~2*(1. Department of Pharmacy, No. 401 Hospital of PLA, Qingdao 266071, China; 2. Department of Drug Analysis, School of Pharmacy, Second Military Medical University, Shanghai 200433; 3. Testing Center, School of Pharmacy, Second Military Medical University; 4. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University);Ultrasonic condition for extraction of flavone from Radix Astragali by orthogonal design[J];Academic Journal of Second Military Medical University;2005-10
2 Peng Shuying,Sheng Jianhua,Ye Yang~* (Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai 201203);Studies on the Mass Spectrometric Behavior of Four Types of Stemona Alkaloids[J];Chinese Journal of Analytical Chemistry;2006-04
3 Zhang Ji-gang1,Lin Chao-peng2 (1. Limin Pharmaceutical Factory,LIVZON Pharmaceutical Group,Shaoguan 512028,China) (2. Yingdong College of Bio-engineering,Shaoguan University,Shaoguan 512005,China);Extracting of Total Flavone from Astragalus membranaceus by Alcohol[J];Modern Food Science and Technology;2006-03
4 YU Zhaoyang,WANG Xiaolin(Department of Chemical Engineering,Tsinghua University,Beijing 100084);Progress in extraction and purification of alkaloids[J];Chemical Industry and Engineering Progress;2006-03
5 CHEN Xin,LIU Ai-wen,CHEN Chun-xin,LIANG Ying-yan,HONG Xiang-le (Foshan Academy of Science and Technology,Foshan 528000,Guangdong,China);Inhibition of Nitrosation by Chitosan and Its Derivatives[J];Fine Chemicals;2005-03
6 WANG De-qing~(1),TIAN Ya-ping~(1),XIANG Lan~(2)(1.Department of Clinical Biochemical,PLA General Hospital,Beijing 100853,China;2.College of Pharmacy,University of Shandong,Jinan 250100,China);Study of total flavonoids of Astragalus's biology action on chemical ingredient[J];Academic Journal of PLA Postgraduate Medical School;2006-01
7 HE Jun 1,2,ZHU Lin 1,FENG Jian-fang 1 (1.Pharmaceutical Division, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437,China; 2.West China School of Pharmacy, Sichuan University, Chengdu 610041,China);Comparison on Determination of Total Alkaloids from Radix Aconiti Lateralis Preparata by Titration and UV[J];Research and Practice of Chinese Medicines;2003-06
8 Yan Qiaojuan(Agricultural Engineering Institute, CAU) Han Lujia(Research and Development Office, East Part, CAU)Jiang Zhengqiang(College of Food Science and Engineering, CAU) Liu Xiangyang(Agricultural Engineering Institute, CAU);Study on the Methods of Extracting and Isolating Astragaloside[J];Journal of China Agricultural University;2000-06
9 Han Lujia Yan Qiaojuan Jiang Zhengqiang Liu Xiangyang (China Agricultural University, Beijing 100083);Study on Extracting Technology of Astragalan Polysaccharide (ASP) and Astragaloside (AS)[J];TRANSACTIONS OF THE CHINESE SOCIETY OF AGRICULTURAL ENGINEERING;2000-05
10 SUN Zhe-hao1 LI Bao-zhen2 ZHAO Mou-ming2 YANG Bao2 (1. Food Science and Engineering Department,Foshan University,Foshan,Guangdong 528000,China; 2. College of Light Industry and Food Technology,South China University of Technology,Guangzhou, Guangdong 510640,China);Optimization of the extraction technology of the total flavonoids of semen litchi using response surface analysis[J];Food & Machinery;2006-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved