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《Journal of Heilongjiang Bayi Agricultural University》 2017-03
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Establishment of Nonalcoholic Fatty Liver Disease Model in Rats

Yang Wei;Xu Chuang;Chen Yuanyuan;Zheng Jiasan;Zhang Hongyou;Xia Cheng;College of Animal Science and Technology,Heilongjiang Bayi Agriculture University;  
To study nonalcoholic fatty liver disease(NAFLD),wistar rats were fed with different high-fat diets to develop NAFLD.In this study,wistar rats were fed with high-fat diets(with or without deoxycholic acid or propylthiouracil)for 6 weeks.Our results showed that rats fed a high-fat diet(H6)gained a significant amount of weight and severe steatosis.Compared with H6 rats,rats which fed with high-fat diets with deoxycholic acid showed decreased liver cholesterol and significant higher serum alaninetransaminase(ALT)and aspartate aminotransferase(AST).The hypothyroid rats induced by propylthiouracil had a fleshless body,significantly higher concentrations of total cholesterol(TC),low-density lipoprotein cholesterol(LDL-c)and ALT concentrations in serum.Hypothyroid rats that had a previous prepared with tetracycline demonstrated severe pathological changes in the liver,lower liver triglyceride accumulation and high serum ALT concentrations.The results suggested that propylthiouracil-induced hypothyroidism played an important role in progressive NAFLD,Hypothyroid rats that had a previous prepared with tetracycline could develop an end-stage liver disease.This find was important for NAFLD research.
【Fund】: 国家自然科学基金青年项目(31502133);; 国家科技支撑计划(2012BAD12B03-2和2013BAD21B01)
【CateGory Index】: R-332;R575.5
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Ying;LIU Xinyu;WANG Shasha;GUO Ze;ZHANG Xuemei;Department of Animal Medicine,Agricultural College of Yanbian University;;Treatment effect of Astragalus extract on acute alcoholic liver injury in mice[J];延边大学农学学报;2016-02
2 Yu Xin;Zhang Qi;Chen Yuanyuan;Zhao Xiangyang;He Yibo;Wang Yuxin;Li Lingzheng;Chen Shuang;Xu Chuang;College of Animal Science and Technology,Heilongjiang Bayi Agricultural University;;Analysis of Present Situation on Model Constructing of High-fat Diet Fatty Liver in Rats[J];黑龙江八一农垦大学学报;2016-01
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 CHU Lan-lan;XU Meng;WANG Yan;HU Yong-di;XU De-xiang;HU Chun-qiu;Department of Nutrition and Food Hygiene, School of Public Health, Anhui Medical University;;Dynamic monitoring of alcohol-induced acute liver injury model in male mice[J];现代预防医学;2017-14
2 Yang Wei;Xu Chuang;Chen Yuanyuan;Zheng Jiasan;Zhang Hongyou;Xia Cheng;College of Animal Science and Technology,Heilongjiang Bayi Agriculture University;;Establishment of Nonalcoholic Fatty Liver Disease Model in Rats[J];黑龙江八一农垦大学学报;2017-03
3 WANG Ying;LIU Xinyu;WANG Shasha;GUO Ze;ZHANG Xuemei;Department of Animal Medicine,Agricultural College of Yanbian University;;Treatment effect of Astragalus extract on acute alcoholic liver injury in mice[J];延边大学农学学报;2016-02
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Yu Xin;Zhang Qi;Chen Yuanyuan;Zhao Xiangyang;He Yibo;Wang Yuxin;Li Lingzheng;Chen Shuang;Xu Chuang;College of Animal Science and Technology,Heilongjiang Bayi Agricultural University;;Analysis of Present Situation on Model Constructing of High-fat Diet Fatty Liver in Rats[J];黑龙江八一农垦大学学报;2016-01
2 Qian Zhengyue;Li Jun;Huang Cheng;School of Pharmacy,Anhui Medical University;Anhui Key Laboratory of Bioactivity of Natural Products;Anhui Institute of Innovative Drugs;;Therapeutical effects of Zhizi Bopi Decoction and its compatibility on CCl_4 induced hepatic fibrosis in mice[J];安徽医科大学学报;2016-01
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5 Wu Shuqin;Wu Dandan;Wang Xin;Ding Fujun;College of Animal Science and Technology,Heilongjiang Bayi Agricultural University;Dongfanghong Township Livestock Station of Hegang;;Research on Different Doses of Acetaminophen Inducing Acute Liver Injury in Rats[J];黑龙江八一农垦大学学报;2015-03
6 CHEN Zhong-qiang;ZHAI Ying;SHANG Ping-ping;ZUO Zheng-yu;LI Qi;LIU Zhi-guo;School of Biology and Pharmaceutical Engineering,Wuhan Polytechnic University;;Effect of cholesterol on nonalcoholic fatty liver disease induced by high-fat[J];武汉轻工大学学报;2015-02
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8 DU Yu-qiong;CHE Nian-cong;ZHAO Hui;FA Zhen-peng;JI Wei-wei;Capital University of Medical Sciences;;Influences of Huangqi( Radix Astragali seu Hedysari) on expressions of TIMP-1 and MMP-1 in liver tissues in rats with liver fibrosis[J];北京中医药大学学报;2013-11
9 XU Lu;LI Yan-ming;LIU Jing-tao;CHENG Yao;ZHANG Xian;ZHANG Xue-mei;Department of Veterinary Medicine,Agricultural College of Yanbian University;Da'an Meteorologic Bureau of Jilin Province;;Effects of Total Flavones of Astragalus on Immune Function in Mice[J];动物医学进展;2013-11
10 SUN Xi-shi;TIAN Jing-ruo;CUI Gui-you;Department of Nutriology, Tourism and Cuisine College of Yangzhou University;;THE PROTECTIVE EFFECTS OF TRIMETHYLPYRAZINE AND TETRAMETHYLPYRAZINE ON ACUTE ALCOHOLIC LIVER INJURY IN MICE[J];营养学报;2013-05
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