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《Heilongjiang Animal Science and Veterinary Medicine》 2018-01
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Progress of peste des petits ruminants virus

LI Linjie;XIE Jun;XU Wenkai;MA Xiaoxia;BAI Jialin;Gansu Engineering Reseanch Center For Animal Cell,Northwest Minzu University;  
Pestes des petits ruminants( PPR) is an acute,highly contagious and fatal disease caused by the Morbillivirus of the family Paramyxoviriaae. The disease is mainly infected with goats and sheep,and the clinical symptoms of cattle is not obvious post infectionem. The disease is classified as an OIE List A disease. The infection and mortality rates can reach 90%. As sheep and goats are important means of production for poor people in Africa and Western Asia,PPR poses a great threat to food security and the fight against poverty. PPR virus( PPRV) and rinderpest virus( RPV) are closely related to Morbilliviruses( MV). Rinderpest has been completely eliminated by mass vaccination. Although the attenuated vaccine can be used to prevent PPRV,this disease has not been effectively controlled because of the instability in subtropical climate( thermo-sensitivity),unavailablity of required doses and insufficient coverage. In addition,there are evidence of poor cross neutralization between vaccine strain and different PPRV strain. It has raised questions about the protective efficacy of the current circulating PPRV vaccine.This paper briefly introduces the high attention to PPRV in the world and the biological characteristics and pathogenesis of PPRV.
【Fund】: 中央专项研究生科研创新项目(Yxm2016139)
【CateGory Index】: S852.65
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