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Immunosuppressants applied in rat limb allograft

The First School of Clinical Medicine,Harbin Medical Univercity Zhang Tao Zhang Xinying Cai Reshan  
It is still the main method to apply immunosuppressants for immunosuppressing actue rejection of the limb allograft in rat.The second generation immunosuppressant-Cyclosporine A and FK-506 could block the activity of Interleukin-2 and are specific for lymphocyte.Immunosuppresssed with CsA and FK-506,Actue rejection could been suppressed effectively and could get pro-longed lived grafed-limb.Furthermore,combination with others have been tried to get better effect.
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