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Expression of P_(16) Protein in Ovarian Epithelial Tumor and its Clinical Significance

Yu Libo Shun Wenzhou Sui Lihua The Third Affiliated Hospital of Harbin Medical University  
Objective:To study P16 expression and distribution in ovarian epithelial tumor and its clinical significance.Methods:P16 protein was detected with immunohistochemical method in 82 cases of ovarian epithelial tumor patients(62 malignant cases)and 15 cases of normal ovarian tissue.Results:The detective rate of P16 in ovarian epithelial carcinoma was 53.2% and lower than in benign tumor 90.0% and in normal tissue 93.3%(p0 01).There was no significance of positive rate between varied differentiation of tumor(p0.05).The expression of P16 was related with its clinical stage and prognosis(p0.05,p0.01).Conclusion:P16 protein might play a role in carcinogenesis and development of ovarian epithelial carcinoma.The deletion expression of P16 might be related with development and prognosis of ovarian carcinoma.
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