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Study of Strontium Mineral Water on Lipid-Lowering Effect in Type 2 Diabetic Rats

WANG Shu,GONG Hui-jie,LI Zhu-hua(Department of Pathophysiology Research,Luzhou Medical College,Luzhou 646000 CHINA)  
Objective To investigate the effect of strontium mineral water combined with glimepiride on liver protection and levels of fasting blood glucose(FBG) and serum lipid in rats with type 2 diabetes mellitus(T2DM).Methods T2DM rat model was established by glucose and intraperitoneal injection of streptozotocin(STZ).The experimental rats were divided into normal group,model control group,strontium mineral water group,tap water glimepiride group and strontium mineral water glimepiride group.The levels of fasting blood glucose were detected every week in all rats.Every two weeks,6 animals were randomly selected and sacrificed from each group for determination of total cholesterol(TC) and triglyceride(TG) in serum and pathological examination of liver.Results In the type 2 diabetes rats model,fasting blood glucose were increased,while the level of TC and TG increased significantly.Glimepiride could decrease the levels of FBG,TC,TG;Although strontium mineral water could not decrease the level of FBG obviously,but TC and TG levels were low significantly;Especially,hypoglycemic and lipid-lowering effects were more significant in strontium mineral water glimepiride group.Conclusion It is suggested that strontium mineral water could reduce the level of serum lipid,have some protective effect for liver,and delay the process of type 2 diabetes in rats.
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