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《Journal of Hunan University(Natural Sciences)》 2014-01
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Estrogenicity Rivalry and Mechanism of Co-existing Hexachlorobenzene and 17-Estradiol

ZHANG Pan-yue;ZHANG Guang-ming;LANG Lang;Key Laboratory of Environmental Biology and Pollution Control(Hunan Univ),Ministry of Education;China School of Environment & Natural Resource,Renmin Univ of China;Research Center on Life Sciences and Environmental Sciences,Harbin Univ of Commerce;  
Hexachlorobenzene's(HCB's)estrogenicity change and potential mechanisms when mixing with a typical natural estrogen,17-Estradiol(E2),were investigated.Human breast cancer cell MCF-7increase examination was used.The results showed that HCB had very strong estrogenicity,but the mixture of HCB and E2showed strong rivalry effect,i.e.,E2and HCB greatly weakened each other on endocrine disrupting effect.Mechanism analyses showed that E2and HCB could interfere with the endocrine system via the endocrine receptor channel and the MAPK signal channel.The rivalry effect between E2and HCB was unrelated with the traditional endocrine receptor channel,but depended strongly on the non-traditional ERK channel.E2decreased the HCB activation of ERK protein,and decreased the expression of p-ERK protein,thus interrupting the transcription of MAPK signal.The transcription factor analyses showed that E2weakened the function of HCB mainly by decreasing the expression of c-Myc protein.
【Fund】: 国家自然科学基金资助项目(51178047);; 芙蓉学者计划资助项目
【CateGory Index】: R114
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 ZHANG Pan-yue1,ZHANG Guang-ming2,LANG Lang3(1.College of Environmental Science and Engineering,Hunan Univ,Changsha,Hunan 410082,China; 2.School of Environment & Natural Resource,Renmin Univ of China,Beijing 100872,China; 3.Research Center on Life Sciences and Environmental Sciences,Harbin Univ of Commerce,Harbin,Heilongjiang 150028,China);Mechanisms of Enhancing Male Toxicity of Nonylphenol by 17-Estradiol[J];Journal of Hunan University(Natural Sciences);2012-11
2 ZHANG Guang-ming1,LANG Lang2,ZHANG Pan-yue3,4(1.School of Environment & Natural Resource,Renmin Univ of China,Beijing 100872,China;2.Research Center on Life Sciences and Environmental Sciences,Harbin Univ of Commerce,Harbin,Heilongjiang 150028,China; 3.Key Laboratory of Environmental Biology and Pollution Control of Ministry of Education,Hunan Univ,Changsha, Hunan 410082,China;4.College of Environmental Science and Engineering,Hunan Univ,Changsha,Hunan 410082,China);Rivalry Effect of E2 and Cd on Estrogenicity and Potential Mechanisms[J];Journal of Hunan University(Natural Sciences);2013-03
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